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Hereditary Pancreatic Cancer | |
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Angiogenesis | |
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Strategies in Gene Therapy | |
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Expansion of the Human Tumor Bank and Database | |
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How to Support the Pancreatic Research Efforts at M. D. Anderson | |
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PTSG Top Web Picks | |
From
Bench to Bedside:
Angiogenesis
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Angiogenesis is a process by which tumor cells develop the blood supply necessary for their ongoing growth and development. A large focus of cancer research is the development of a better understanding of this process to allow cancer therapies to be directed specifically at inhibiting angiogenesis. A major focus of our current laboratory effort is to better understand the molecular mechanism of tumor-induced angiogenesis and to study novel antiangiogenic treatments in our recently-developed mouse model of human pancreatic cancer. |
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Selected References: 1. Ellis LM, Takahashi Y, Fenoglio CJ, Cleary KR, Bucana CD, Evans DB. Vessel counts and vascular endothelial growth factor expression in pancreatic adenocarcinoma. Eur J Cancer 1998; 34:337-340. 2. Bold RJ, Hes KR, Pearson AS, Grau AM, Sinicrope FA, Jennings M, McConkey DJ, Bucana CD, Cleary KR, Chiao PJ, Abbruzzese JL, Evans DB. Prognostic factors in resectable pancreatic cancer: p53 and bcl-2. In press: Gastrointestinal Surg. 3. Kuniyasu H, Ellis L, Evans DB, Abbruzzese JL, Fenoglio CJ, Bucana CD, Cleary KR, Tahara E, Fidler IJ. Expression of metastasis-related genes predicts outcome in patients with resectable pancreatic carcinoma. In press: Clin Cancer Res. 4. Sinicrope FA, Evans DB, Leach SD, Cleary KR, Fenoglio CJ, Lee J, Abbruzzese JL. bcl-2 and p53 expresion in resectable pancreatic adenocarcinomas: association with clinical outcome. Clin Cancer Res 1996;2:2015-2022. |