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Hereditary Pancreatic Cancer | |
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Angiogenesis | |
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Strategies in Gene Therapy | |
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Expansion of the Human Tumor Bank and Database | |
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How to Support the Pancreatic Research Efforts at M. D. Anderson | |
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PTSG Top Web Picks | |
From
Bench to Bedside:
Hereditary Pancreatic Cancer
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There is recent evidence to suggest that in selected families pancreatic cancer may be inherited due to the inactivation of tumor suppressor genes. Such genes, when inactivated due to a mutation, result in uncontrolled cellular proliferation and transformation of normal cells into cancer cells. Our Pancreatic Tumor Database in collaboration with other large referral centers is attempting to determine the exact genes responsible for inherited pancreatic cancer. |
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Selected References: 1. Abbruzzese JL, Evans DB, Raimman I, Larry L, King T, Leach SD, Frazier ML. Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer. Anticancer Res 1997;17:795-802. 2. Evans, DB, Frazier ML, Charnsangavej C, Katz RL, Larry L, Abbruzzese JL. Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique. Ann Surg Oncol 1996;3:241-246. |