James L. Abbruzzese, M.D. -
Chairman, Gastrointestinal Medical Oncology

Dr. Abbruzzese is one of the world's foremost leaders in the clinical study and treatment of pancreatic cancer. He is Board Certified in Internal Medicine and Medical Oncology with his major clinical and Laboratory interest being in pancreatic cancer, new drug development and evaluation, and unknown primary tumors.

Education:

• Medical School: University of Chicago Pritzker School of Medicine, Chicago, IL
• Residency (Internal Medicine): Johns Hopkins Hospital, Baltimore, MD
• Fellowship (Clinical Infectious Disease): Johns Hopkins Hospital, Baltimore, MD
• Fellowship (Clinical Medical Oncology ): Harvard Medical School Dana-Faber Cancer Institute, Boston, MA

Selected References :

1. Lenzi R, Hess KR, Abbruzzese MC, Raber MN, Oronez N, Abbruzzese JL: Poorly differentiated carcinoma and poorly differentiated adenocarcinoma of unknown origin: Favorable Subsets of Patients with Unknown Primary Carcinoma? J Clin Oncol 15:2056-2066, 1997.

2. Grau AM, Zhang L. Wang W, Evans DB, Abbruzzese JL, Chiao PJ: Induction of p21waf1 expression and growth inhibition by transforming growth factor - is mediated by the tumor suppressor gene DPC-4 in human pancreatic adenocarcinoma cells. Cancer Res 57:3929-3934m 1997.

3. Wang M, Abbruzzese JL, Friess H, Hittelman WN, Evand DB, Abbruzzese MC, Chiao PJ, Li D: DNA adducts in human pancreatic tissues and their potential role in carcinogenesis. Cancer Res, 58:38-41, 1998.

4. Robinson EK, Grau AM, Evans DB, Smid CM, Chiao PJ, Abbruzzese JL, Grimm EA: Tamoxifen induces cell cycle arrest in human pancreatic cancer. Ann Surg Oncol

5:342-349, 1998. 5. Ayoub JP, Hess KR, Abbruzzese MC, Lenzi R, Raber MN, Abbruzzese JL: Unknown primary tumors metastastatic to liver. J Clin Oncol 16:2105-2112, 1998.