Category A
Rationale/Protocol ID 98-020
Multi-Institutional Phase II Study of Preoperative Rapid-Fractionation External-Beam Radiation Therapy and Concomitant Gemzar (gemcitabitne) for Patients with Resectable Adenocarcinoma of the Pancreatic Head
| Recent evidence suggesting
activity for gemcitabine in patients with metastatic pancreatic cancer
combined with recent evidence supporting its use as a radiation sensitizer
provide the rationale for the combination of external-beam radiation
therapy and gemcitabine. Previous work from our institution has demonstrated
the safety of gemcitabine when delivered in seven weekly infusions.
This protocol builds upon our recently completed phase I study of
Gemzar-based chemoradiation for patients with localized adenocarcinoma
of the pancreas.
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