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Breast Cancer Nomogram to Predict Positive Sentinel Lymph Nodes, after Neoadjuvant Chemotherapy

This software calculates the probability of finding positive sentinel lymph nodes in clinically node negative breast cancer patients who have been treated with neoadjuvant (preoperative) chemotherapy. This nomogram was developed at the University of Texas MD Anderson Cancer Center and has not yet been externally validated.

Enter age at diagnosis, in years. Must be between 27 and 87.
Choose the histologic type of the tumor.
Modified Black's Nuclear Grade
Maximum size of the primary tumor (largest single dimension), in centimeters, on preoperative imaging studies.
Measure the maximum tumor size (single dimension) on imaging before and after neoadjuvant chemotherapy and calculate the percent decrease in size. Note: if the tumor increased in size after neoadjuvant chemotherapy, the increase should be entered as a negative number
Indicate whether tumor was located in more than one location in the breast.
Indicate whether tumor cells were present in blood vessels or lymphatic structures.
Indicate whether the tumor is negative for expression of estrogen receptor (ER), progesterone receptor (PR) and HER/2 neu. Select "YES" if tumor is negative for all three and select "NO" if tumor is positive for any one, or more, of these markers.

L. Allen, R. Bassett, P. Gadgil, G.V. Babiera, I. Bedrosian, K.K. Hunt, H.K. Kuerer, F. Meric-Bernstam, E.A. Mittendorf, M.I. Ross, M. Yi and R.F. Hwang. Presented at the American Society of Clinical Oncology (ASCO) Breast Cancer Symposium, September 2012.