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CANCELLED-Pediatrics Research Seminar Series:  Regulation of the Assembly and Function of Cullin-RING Ubiquitin Ligases

CANCELLED-Pediatrics Research Seminar Series: Regulation of the Assembly and Function of Cullin-RING Ubiquitin Ligases

The Department of Pediatrics Research invites investigators with expertise in the field of pediatric tumors or relevant areas of research to present the recent findings to faculty, students and post-doctoral fellows.

Date: 1/8/13, 9am to 10am
Time: 1/8/13, 9am to 10am
Location: Smith Research Building, Conference SRB1.122
Format: Seminar/Conference
Facilitator: Vidya Gopalakrishnan, PhD
Speaker: Raymond Deshaies, PhD
Speaker Bio: Raymond Deshaies, PhD is a Professor and Investigator at California Institute of Technology. Cullin-RING ubiquitin ligases (CRLs) comprise a large family of ~250 enzymes. SCF and other CRL enzymes play key roles i the regulatory biology of normal and diseased cells. Some CRLs have been implicated as tumor suppressors whereas others have a proto-oncogenic function. Given the large number of different CRL complexes that can be assembled in cells, a key question is how the repertoire of CRL enzymes is regulated to yield the appropriate balance of growth-promoting (eg SCF-Skp2) and growth-restraining (eg SCF-Cdc4) activities. In my seminar, I will discuss recent advances that have been enabled us to develop a specific and general model that explains how the cellular repertoire of CRL complexes is determined.
Contact: Hector Jimenez - (713) 563-5394 - jhjimene@mdanderson.org