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CCAR2 as a Target for Prevention of Colorectal Cancer

CCAR2 as a Target for Prevention of Colorectal Cancer

The Division of Cancer Prevention and Population Sciences, Cancer Prevention & Control Grand Rounds presents Dr. Roderick H. Dashwood from Texas A&M University Health Science Center to speak on April 7, 2017. 

Date: 4/7/17, 12pm to 1pm
Time: 4/7/17, 12pm to 1pm
Location: Mays Clinic, ACB, 1.2325ABC First Floor
Format: Grand Rounds
CME: 1
Speaker: Dr. Roderick H. Dashwood
Speaker Bio: Dr. Dashwood has been interested for >25 years in the prevention of colorectal cancer. This work spans the continuum from in silico docking and computational modeling, molecular mechanistic studies in vitro and in cell-based assays, preclinical studies using genetic and carcinogen-induced rat and mouse models, and translation into human volunteers. Initial work focused on the genetic aspects of colorectal cancer, with the cloning of the rat -catenin (Ctnnb1) gene and characterization of its promoter. This research moved into the realm of epigenetics with the discovery of the histone deacetylase inhibitory mechanism of sulforaphane in human colon cancer cells. The work expanded to other areas, including histone and non-histone modifications, DNA methylation, and non-coding RNAs, in patients undergoing screening colonoscopy. The PI’s laboratory recently pioneered a murine polypectomy methodology and established its utility for primary and secondary prevention studies using dietary factors and anticancer agents.
Contact: Jennifer Castillo - (832) 750-1629 - jmcastillo1@mdanderson.org