Skip to Content

MD Anderson Events

John H. Blaffer Lecture Series

John H. Blaffer Lecture Series

 

Gregory David, Ph.D.
Associate Professor, Co Course Director
 Dept. of Biochemistry and Molecular Pharmacology
New York University School of Medicine
New York, NY
 
 
“Chromatin modifiers: At the nexus of transcription and cancer”
 
 
Host: Xiaobing Shi, Ph.D.
Biochemistry & Molecular Biology

Date: 10/22/13, 4pm to 5pm
Time: 10/22/13, 4pm to 5pm
Location: Onstead Auditorium, Basic Science Research Building, Floor 3, near Elevator J, (S3.8012)
Format: Lecture
CME: 0
Facilitator: Nicholas Navin
Speaker: Gregory David
Speaker Bio: The research interests of our laboratory center on chromatin modifications and its impact on regulation of gene expression and nuclear structure, particularly as it relates changes associated with malignant transformation. Clearly, the interplay between activation and repression of transcription that imposes normal transcriptional control becomes disrupted in cancer. Besides their roles in promoter-specific transcriptional regulation, histone modifiers also play a role in the establishment of large chromosomal domains, and therefore function in maintenance of chromosomal integrity. We and others have shown that deregulation of histone modifying complexes, including Histone Deacetylases (HDACs)-containing complexes, participate to the oncogenic transformation in numerous human cancers. Several studies suggested that blocking the enzymatic activity of HDAC complexes (e.g., using histone deacetylase inhibitors) could prevent tumorigenesis and selectively induce cell death in transformed cells. While HDACs are integral components of several gene regulatory complexes, HDAC inhibitors developed to date exhibit little or no specificity towards individual HDAC-containing complex. Thus, the identification of pathways involved in the modulation of the activities of specific HDAC complexes is a priority in cancer therapy. Knowledge of these control mechanisms in both normal physiology and malignancy is essential for the better understanding of the malignant process that will allow development of novel therapeutic and diagnostic approaches to human disease. Research Interests Chromatin modifications in development and oncogenesis
Contact: Doris Green - dlgreen1@mdanderson.org