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MD Anderson Events

John H. Blaffer Lecture Series

John H. Blaffer Lecture Series

 

Jody Rosenblatt, Ph.D.
Assistant Professor
 Oncological Sciences
 University of Utah School of Medicine
Huntsman Cancer Institute
Salt Lake City, UT
 
 
“Epithelial apoptosis: death by extrusion”
 
 
Host: Michael Galko, Ph.D.
Biochemistry & Molecular Biology

Date: 11/5/13, 4pm to 5pm
Time: 11/5/13, 4pm to 5pm
Location: Onstead Auditorium, Basic Science Research Building, Floor 3, near Elevator J, (S3.8012)
Format: Lecture
CME: 0
Facilitator: Nicholas Navin
Speaker: Jody Rosenblatt
Speaker Bio: Research We have identified a process all epithelia use to remove dying cells without disrupting barrier function called ‘cell extrusion’. We study extrusion using cell culture epithelia and zebrafish epidermis (see example of a dying extruding cell). To extrude, a cell destined to die produces and emits a bioactive lipid Sphingosine 1-Phosphate (S1P), which binds to a G-protein coupled receptor (S1P2) in the neighboring cells to form a contractile actin/myosin band that squeezes the cell out without disrupting the epithelial barrier (Gu et al, JCB 2011). Recently we have found that normal epithelial cell death depends on first extruding live cells.
Contact: Doris Green - (713) 834-6267 - dlgreen1@mdanderson.org