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The Department of and Bioinformatics and Computational Biology and Distinguished Guest Lecture Series

The Department of and Bioinformatics and Computational Biology and Distinguished Guest Lecture Series

Rafael A. Irizarry, Ph.D.

Professor,
Biostatistics
Johns Hopkins University

Bump hunting in the Cancer Epigenome

Epigenetics is the study of nonsequence-based changes, such as DNA methylation, heritable during cell division. I will start the talk with a short tutorial on epigenetics and DNA methylation. I will describe new challenges for statisticians related to the existing field of bump hunting. I will describe the important role modern statistical techniques play in finding regions of the genome that are consistently different between disease and normal groups using both microarray and next-generation sequencing data. I will also describe the batch effect and how we deal with it. Finally, I will present some interesting Biological results related to development and cancer.

Date: 11/7/12, 11am to 12pm
Time: 11/7/12, 11am to 12pm
Location: FCT2.4142 Room B
Format: Lecture
Facilitator: Roel Verhaak
Speaker: Rafael Irizarry
Speaker Bio: Rafael A. Irizarry, Ph.D. Professor, Biostatistics Johns Hopkins University
Contact: Teresa Gonzales - 30299 - teresa.gonzales@mdanderson.org