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DTSTART:20061101T020000
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UID:1369330193804.mdanderson.org
ORGANIZER;CN=Pierre McCrea, PhD:MAILTO:pdmccrea@mdanderson.org
DTSTAMP:20130523T122953
DTSTART;TZID=Central Standard Time:20130118T120000
DTEND;TZID=Central Standard Time:20130118T130000
SUMMARY:Signal transduction at junctions: coupling adhesion and actomyosin dynamics at E-cadherin contacts
LOCATION:One Baylor Plaza - Michael E. DeBakey Center - Room: M112
DESCRIPTION:\n Cells are the building blocks of our bodies. Interactions between different cells are important to shape our developing bodies and maintain the organisation of our tissues in health. A range of diseases occur when those interactions are disturbed, including cancer and inflammation.  \nDr. Yap's laboratory is focused on understanding how cadherins cooperate with the actin cytoskeleton, long believed to be central to cadherin function. Their findings indicate that this cooperation involves a complex interplay between adhesion receptors and diverse distinct states of the cytoskeleton, coordinated by a variety of signalling pathways at the cell membrane. In particular, Dr. Yap's work demonstrates that cadherins function as adhesion-activated cell signalling receptors that stimulate pathways to regulate the actin cytoskeleton, thereby influencing cell shape, adhesion, and cell-cell cohesion. Relevant signals include the Rho family GTPases and Src family kinases. These affect a range of cytoskeletal regulators, including actin nucleators, cross-linking proteins, scaffolds and the myosins II and VI. The group aims to understand the dynamic spatial and temporal regulation of the cytoskeleton by cadherin signalling, with a view to understanding how these key elements are used during development and tissue maintenance, and how they are disrupted in human disease. \n \n\nLocation   : One Baylor Plaza - Michael E. DeBakey Center - Room: M112\nFormat     : Seminar/Conference\nFacilitator: Pierre McCrea, PhD\nSpeaker    : Professor Alpha Yap, MD/ PhD\nSponsor    : Pierre McCrea, PhD\nContact    : Pierre McCrea, PhD - (713) 834-6277 - pdmccrea@mdanderson.org\n\nEvent URL  : http://www3.mdanderson.org/calendar/event/Signal_transduction_at_junctions_coupling_adhesion_and_actomyosin_dynamics_at_Ecadherin_contacts_18642.html
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