Giovanni Parmigiani, Ph.D.
Over the last decade Bayesian hierarchical
models have been increasingly used in numerous areas,
including clinical trials and epidemiological studies. This is now a well
established methodology for handling study-to-study heterogeneity, small sample
sizes, heterogeneous study designs, publication bias, and other
complexities. The necessary computations
for fitting Bayesian hierarchical models in a wide range of situations can be
carried out conveniently using standard software packages such as BUGS. As results from Bayesian hierarchical models are
increasingly used to support clinical and policy decision making, the issue
arises of whether they provide a sound way for comparing treatments. In this
case study we will consider a meta-analysis of 2x2 tables, each arising from a
study comparing adverse event counts for a treatment arm and a control arm. Our
analysis will highlight strengths as well as important potential limitations of
Bayesian hierarchical approaches, and will emphasize approaches that ensure
robustness of conclusions to modeling choices such as parameterization,
distributional assumptions and prior hyperparameters. |