Bharat ("Bart") Bhushan Aggarwal, Ph.D.
The primary interest of my laboratory is in the area of cytokines as regulators of tumor cell growth. The specific aims of our Cytokine Research section are as follows: (a) identification of novel antiproliferative agents that are specific to tumor cells and (b) investigation of mechanisms by which tumor cells develop resistance to cytokines and examination of methods to overcome this resistance.

In collaboration with Human Genome Sciences (Boston, MA), we identified several novel cytokines and cytokine receptors that are members of the TNF and TNF receptor superfamily, respectively. We also discovered that genes regulated by the transcription factor NF-kappaB may play a major role in resistance to apoptosis induced by TNF and certain chemotherapeutic agents. Since NF-kappaB also regulates the genes involved in tumor proliferation and metastasis, we demonstrated that several known anticarcinogenic agents are potent inhibitors of NF-kappaB activation. Our results also indicated that the early steps in the pathway leading to apoptosis and NF-kappaB activation overlap.

Professor of Medicine (Biochemistry) and Chief
Cytokine Research Section
Department of Molecular Oncology
The University of Texas M. D. Anderson Cancer Center
Houston, Texas

Adjunct Professor
Albert B. Alkek Institute of Biosciences and Technology (IBT)
Texas A&M University
Houston, Texas

Cytokine Research Section
Department of Molecular Oncology, Box 143
University of Texas
M. D. Anderson Cancer Center
1515 Holcombe Boulevard
Houston, Texas 77030, USA
Phone: (713) 792-3503
Fax: (713) 794-1613
E-mail: aggarwal@utmdacc.mda.uth.tmc.edu

Scientist and Group Leader in the Department of Protein Biochemistry at Genentech, Inc.
South San Francisco, CA.

1. Editorial Board of The Journal of Biological Chemistry (1996-Present).
2. Editorial Board of Antioxidants and Redox Signalling (1999-Present).
3. Editorial Board of Journal of Interferon and Cytokine Research (1989-Present).

1. Shrivastava A., and Aggarwal B. B., Antioxidants Differentially Regulate Activation of Nuclear Factor- B (NF- B), Activator Protein-1, c-Jun N-Terminal Kinases (JNK), and Apoptosis Induced by Tumor Necrosis Factor. Antioxidants & Redox Signaling. (in press).

2. Giri D. K., Pantazis P. and Aggarwal B. B., Cellular Resistance to Vincristine Suppresses NF-kB Activation and Apoptosis but Enhances c-Jun-NH2-Terminal Protein Kinase Activation by Tumor Necrosis Factor. APOPTOSIS (in press)

3. Mukhopadhyay A., Ni J., Zhai Y., Yu G-L. and Aggarwal B. B., Identification and Characterization of a Novel Cytokine, THANK, a TNF Homologue that Activates Apoptosis, Nuclear Factor-kB, and c-Jun N-Terminal Kinase J. Biol. Chem. (Rapid Communication) 274, 15978-15981, 1999

4. Manna S. K., Kuo M.T., and Aggarwal B. B. Overexpression of -Glutamylcysteine Synthetase Abolishes Tumor Necrosis Factor-Induced Apoptosis and Activation of Nuclear Transcription Factor-kappa B and Activator Protein-1 Oncogene. (in press).

5. Govindrajan R., Manna S. K., Aggarwal B. B. and Jadhav A. L., Lead Activates Nuclear Transcription Factor-kB, Activator Protein-1, and Amino-Terminal c-Jun Kinase in Pheochromocytoma Cells. Toxicology and Applied Pharmacology. 155, 280-286, 1999.

6. Darnay B., Ni J., Moore P. A. and Aggarwal B. B. Activation of NF-kB by RANK Requires TRAF6 and NF-kB-Inducing Kinase (NIK): Identification of a novel TRAF6 interaction motif. J. Biol. Chem. 274, 7724-7731, 1999

7. Krishnamoorthy R.R., Crawford M.J., Chaturvedi M. M., Jain S.K., Aggarwal B. B., Al-Ubaidic M. R., and Agarwal N. Photo-oxidative stress down-modulates the activity of nuclear factor-kappa B (NF-kB) leading to apoptosis of photoreceptor cells. J. Biol. Chem. 274, 3734-3743, 1999

8. Manna S. and Aggarwal B. B. Immunosuppressive Leflunomide Metabolite (A77 1726) Blocks TNF-dependent Nuclear Factor-kB activation and Gene expression J. Immunol. 162, 2095-2102, 1999.

9. Manna S. and Aggarwal B. B. Lipopolysaccharide inhibits TNF-induced apoptosis: Role of NF-kB activation and reactive oxygen intermediates J. Immunol. 162, 1510-1518, 1999

10. Zhai Y., Ni J., Jiang G-W., Lu J., Xing L., Lincoln C., Janat F., Kozak D., Rojas J., Aggarwal B. B., Ruben S., Li L., Gentz, R., and Yu G. VEGI, A novel cytokine of the TNF family, is an angiogenesis inhibitor that suppresses the growth of colon carcinoma in vivo. FASEB J 13: 181-189, 1999.

11. Manna S., Gad Y., Mukhopadhyay A. and Aggarwal B. B., Suppression of Tumor Necrosis Factor-activated Nuclear Transcription Factor-kB, Activator Protein-1, c-Jun N-terminal kinase and Apoptosis by -Lapachone Biochem. Pharmacol. 57, 763-774, 1999.

12. Aggarwal B. B. Haridas V. and Chainy G. B. N. Role of two types of TNF receptors in activation of nuclear factor NF- B, C-Jun N-terminal kinase and apoptosis in Proceeding of the 10th International Congress of Immunology 493-497, 1998.

13. Manna S. and Aggarwal B. B., Interleukin-4 downregulates both forms of TNF receptor and receptor-mediated apoptosis, NF-kB, AP-1 and c-Jun N-terminal kinase: Comparison with Interleukin-13 J. Biol. Chem. 273, 33333-33341, 1998.

14. Shrivastava A. , Manna S., Ray R. B., and Aggarwal B. B., Hepatitis C virus core protein differentially regulates Nuclear Transcription Factor-kB and Activation Protein-1. J. Virol. 72, 9722-9728, 1998.

15. Pan G., Bauer J. H., Haridas V.,Wang S., Liu D., Yu G., Vincenz C., Aggarwal B. B., Ni J., and Dixit V.M., Identification and functional characterization of DR6, a novel death domain-containing TNF receptor FEBS Lett. 434, 351-356, 1998.

16. Singh S., Raju U., Mendoza J., Pantazis P. and Aggarwal B. B., Acquisition of Cellular Resistance to 9-Nitro-Camptothecin xorrelates witha suppression of Transcription Factor NF- B activation and potentiation of cytotoxicity by Tumor Necrosis Factor in human histiocytic lymphoma U-937 Cells. Anti-Cancer Drugs 9, 703-714, 1998.

17. Giri D. K., Mehta R. T., Kansal R. G., and Aggarwal B. B., Mycobacterium avium intracellulare complex activates Nuclear Transcription Factor-kB in different cell types through reactive oxygen intermediates. J. mmunol. 161, 4834-4841, 1998

18. Darnay B., Haridas V., Ni J., Moore P. A. and Aggarwal B. B., Characterization of the intracellular domain of receptor activating NF-kB (RANK): Interaction with TNF-receptor associated factor (TRAF)s and activation of NF-kB and c-Jun N-terminal kinase. J. Biol. Chem. 273, 20551-20555, 1998

19. Manna S. and Aggarwal B. B., -Melanocyte Stimulating Hormone inhibits the Nuclear Transcription Factor NF-kB activation induced by various inflammatory agents. J. Immunol. 161, 2873-2880, 1998.

20. Manna, SK and Aggarwal BB. Interleukin-13 suppresses TNF-induced activation of Nuclear Factor-kB, Activation Protein-1, and apoptosis J. Immunol. 161, 2863-2872, 1998.

21. Haridas V. , Ni J., Meager A., Su, J., Yu, G-L., Zhai, Y., Kyaw H., , Akama, K. T., Hu, J., Van Eldik, L., and Aggarwal B. B. TRANK, a novel cytokine that activates NF-kB and c-Jun N-terminal kinase J. Immunol. (Cutting Edge) 161, 1-6, 1998.

22. Kumar A., Manna S. K. Dhawan S., and Aggarwal B. B., Human Immunodeficiency Virus-1 tat protein activates c-Jun N-terminal kinase and Activator Protein-1. J. Immunol. 161, 776-781, 1998.

23. Giri D. K., and Aggarwal B. B., Constitutive activation of NF-kB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells: Autocrine role of TNF and reactive oxygen intermediates. J. Biol. Chem. 273, 14008-14014, 1998.

24. Manna S., Zhang, H. J., Yan T., Oberley L. W., and Aggarwal B. B., Overexpression of Mn-superoxide dismutase suppresses TNF induced apoptosis and activation of Nuclear Transcription Factor-kB and Activated Protein-1. J. Biol. Chem. 273, 13245-13254, 1998.

25. Kumar K., Dhawan S., and Aggarwal B. B., Emodin (3-methyl-1,6,8-trihydroxyanthraquinone ) inhibits the TNF-induced NF- B activation, I B degradation and expression cell surface adhesion protein in human vascular endothelial cells. Oncogene 17, 913-918, 1998.

26. Chintala S. K., Sawaya R., Giri D. K., Aggarwal B. B., Majumder S., Kyritsis A.P.. and Rao J. S., Induction of matrix metalloproptease-9 requires a polymerized actin cytoskelaton in human malignant glioma cells. J. Biol. Chem. 273, 13545-13551, 1998.

27. Kwon B.S., Wang S., Udagawa N., Haridas V., Kim K. K., Oh K-O., Lee Z.H., Greene J., Li Y., Ruben S. M., Gentz R., Aggarwal B. B., and Ni J., A new member of the tumor necrosis factor receptor superfamily TR1, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. FASEB J. 12, 845-854, 1998.

28. Ray R. B., Meyer K., Steele R., Shrivastava A., Aggarwal B. B., and Ray R., Inhibition of tumor necrosis factor mediated apoptosis by hepatitis C virus core protein. J. Biol. Chem. 273, 2256-2259, 1998.

29. Haridas V., Darnay B., Natarajan K., Heller R., and Aggarwal B. B., Over-expression of the p80 TNF receptor leads to TNF-dependent apoptosis, NF- B activation, and c-Jun kinase activation, J Immunol. 160, 3152-3162, 1998.

30. Natarajan K., Manna S. K., Chaturvedi M. M., and Aggarwal B. B., Protein tyrosine kinase inhibitors block TNF-induced activation of NF-k , degradation of Ik , nuclear translocation of p65 and subsequent gene expression. Arch. Biochem. Biophys. 352: 59-70, 1998.

31. Mukherjee R., Singh S., Chaturvedi M., and Aggarwal B. B., Evidence for synergistic role of two types of human tumor fecrosis factor receptors for the ligand-dependent activation of the nuclear transcriptionfactor NF-kB J. Interferon and Cytokine Res. 18, 117-123, 1998.

32. Wright-Browne V., Schnee A. M., Jenkins M. A., Thall P. F., Aggarwal B. B., Talpaz M., and Estrov Z. Serum cytokine levels in infectious mononucleosis at diagnosis and convalescence. Leukemia and Lymphoma, 30, 583-589, 1998.

33. Kumar A., Dhawan S., Hardegen N. J. and Aggarwal B. B. Curcumin (Diferuloylmethane) inhibition of TNF-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor- B activation, Biochem. Pharmacol. 55, 775-783, 1998.

34. Chaturvedi M., Kumar A., Darnay B., Chainy G. B. N., Agarwal S. and Aggarwal B. B. Sanguinarine (Pseudochelerythrine) is a potent inhibitor of NF-k activation, Ik phosphorylation, and degradation J. Biol. Chem. 272, 30129-30134, 1997.

35. Estrada L. S., Champion H. C., Wang R., Rajasekaran M., Hellstrom W. J. G., Aggarwal B. B. and Sikka S. C., Effect of Tumor Necrosis Factor- (TNF- ) and Interferon- (IFN- ) on Human Sperm Motility, Viability and Motion Parameters. Intl. J. Andrology 20, 237-242, 1997.

36. Darnay B. G. and Aggarwal B. B. Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine 331 in the p60 TNF receptor and inactivates the receptor-associated kinase. FEBS Lett. 410, 361-367, 1997.

37. Dhawan S., Singh S. and Aggarwal B. B. Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: Role of the nuclear transcription factor NF-kB Eur. J. Immunol. 27, 2172-2179, 1997.

38. Shi E. Y., Ni, J., Xiao, G., Liu Y. E., Fuchs A., Yu, G., Su, J., Cosgrove J. M., Xing, L., Zhang, M., Li, J., Aggarwal, B. B., Meager, A., and Gentz, R. Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG. Cancer Res. 57, 3084-3091, 1997.

39. Mehta K., Pantazis P., McQueen T. and Aggarwal B. B. Curcumin (Diferuloylmethane) is a potent antiproliferative agent against human breast tumor cell lines. Anti-Cancer Drugs 8, 470-481, 1997.

40. Dhawan S., Puri R. K., Kumar A., Duplan H., Masson J-M. and Aggarwal B. B. Human immunodeficiency virus -1-tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule -1, and intercellular adhesion molecule -1 in human endothelial cells. Blood 90, 1535-1544, 1997.

41. Darnay B. G., Singh S., and Aggarwal B. B. The p80 TNF receptor-associated kinase (p80TRAK) associates with residues 354-397 of the p80 cytoplasmic domain: Similarity to casein kinase 1. FEBS Lett. 406: 101-105, 1997.

42. Higuchi, M., Aggarwal, B.B. and Yeh E. T. H. Activation of CPP32-like protease in TNF-induced apoptosis is dependent on mitochondrial function. J Clin. Invest. 99: 1751-1758, 1997.

43. Aggarwal B. B., Schwarz L., Hogan M.E. and Rando R.F. Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells. Cancer Res. 56: 5156-5164, 1996.

44. Singh, S., Natarajan, K., and Aggarwal, B. B. Capsaicin (8-methyl-N-vanillyl-6-nonenamide) Is a Potent Inhibitor of Transcription Factor NF-k Activation by Diverse Agents. J. Immunol. 157: 4412-4420, 1996.

45. Singh S., Darnay B. G., and Aggarwal B. B. Site-specific tyrosine phosphorylation of I B negatively regulates its inducible phosphorylation and degradation. J. Biol. Chem. 271, 31049-31054, 1996.

46. Chainy G.B.N., Singh S., Raju U., and Aggarwal B. B. Differential activation of the nuclear factor-k by TNF muteins-specific for the p60 and p80 TNF receptors J. Immunol. 157:2410-2417, 1996.

47. Natarajan K., Singh S., Burke Jr. T.R., Grunberger D. and Aggarwal B. B. Caffeic acid phenethyl ester (CAPE) is a potent and specific inhibitor of activation of nuclear transcription factor NF-k . Proc. Natl. Acad. Sci. U.S.A. 93: 9090-9095, 1996.

48. Husain S.R., Leland P., Aggarwal B. B. and Puri, R.K. Transcriptional upregulation of interleukin-4 receptors by human immunodeficiency virus type 1 tat gene. AIDS Res. Hum. Retroviruses, 12: 1349-1359, 1996.

49. Higuchi M., Singh S., Jaffrezou J-P. , and Aggarwal B. B. Acidic sphingomyelinase-generated ceramide is needed but not sufficient for tumor necrosis gactor-induced apoptosis and NF-kB activation J. Immunol. 156: 297-304, 1996.

50. Totpal K., Singh S., LaPushin R., and Aggarwal B. B., Qualitative and quantitative difference in the cellular responses mediated through fas antigen and tumor necrosis factor receptor. J. Interferon and Cytokine Res. 16: 259-267, 1996.

51. Singh S. and Aggarwal B.B., Activation of transcription factor NF-k is suppressed by curcumin (Diferulolylmethane) J. Biol. Chem. 270: 24995-25000, 1995.

52. Darnay, B.G., Chaturvedi, M.M., Singh S., and Aggarwal, B.B. The p60 TNF receptor-associated kinase (TRAK) binds residues 344-397 within the cytoplas-mic domain involved in TNF signaling. J. Biol. Chem. 270: 14867-14870, 1995.

53. Singh, S. and Aggarwal, B.B. Protein tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription Factor NF-kB. J. Biol. Chem. 270: 10631-10639, 1995.

54. Aggarwal B. B., Pocsik E., and Totpal K. Transfection of cells with basic fibroblast growth factor and kaposi fibroblast growth factor genes induce resistance to and receptor modulation of tumor necrosis factor. FEBS Lett . 372: 44-48, 1995.

55. Higuchi, M., Singh, S., Chan, H., and Aggarwal, B.B. Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, NF- B activation, cytotoxicity and differentiation. Blood: 86(6):2248-2256. 1995.

56. Pocsik, E., Mihalik, R., Chen, H., Penzes, M., Loetscher, H., Gallati, H., and Aggarwal, B.B. Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors. J. Cell. Biochem. 59: 303-316, 1995.

57. Totpal, K., Chaturvedi, M.M., and Aggarwal, B.B. Retinoids down-regulate both p60 and p80 form of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells. Blood 85: 3547-3555, 1995.

58. Aggarwal, B. B., Totpal K., LaPushin R., Chaturvedi M. M., Pereira-Smith O-M and Smith J. R. Diminished responsiveness of senescent normal human fibroblasts to TNF-dependent proliferation and interleukins production is not due to its effect on the receptors or on the activation of a nuclear factor NF- kB, Exptl. Cell Res. 218: 381-388, 1995.

59. Higuchi, M., Singh S. and Aggarwal, B.B. Characterization of the apoptotic effects of human tumor necrosis factor: development of highly rapid and specific bioassay for human tumor necrosis factor and lymphotoxin using human target cells. J Immunol Methods 178:173-181, 1995.

60. Sella, A., Aggarwal, B.B., Kilbourn, R. G., Bui, C. A., Zukiwski A. A. and Logothetis, C. J. Phase I study of tumor necrosis factor plus actinomycin D in patients with androgen-independent prostate cancer. Cancer Biotherapy 10: 225-235, 1995.

61. Leland P., Obiri N., Aggarwal B.B., and Puri R.K. Suramin blocks binding of interleukin-4 to its receptors and interleukin-4 induced mitogenic response. Oncology Res. 77(5):227-235, 1995.

62. Estrov, Z., Samal, B., LaPushin, R., Kellokumpu-Lehtinen, P., Sahin, A.A., Kurzrock, R., Talpaz, M., and Aggarwal, B.B. Leukemia inhibitory factor binds to human breast cancer cells and stimulates their proliferation. J. Interferon and Cytokine Res. 15: 905-913, 1995.

63. Aggarwal B.B., Singh S., LaPushin R. and Totpal K. Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor. FEBS Lett. 364: 5-8, 1995.

64. Aggarwal, B.B., Pocsik, E., Totpal, K., and Ali-Osman, F. Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor-B/c-sis gene. FEBS Lett. 357:1-6, 1995.

65. Puri, R.K., Leland, P., and Aggarwal, B.B. Constituitive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin-2 and interleukin-2 receptor expression in a human CD4+T lymphoid (H9) cell line. AIDS Res. Hum. Retroviruses, 11(1):31-40, 1995.

66. Chan, H. and Aggarwal, B.B. Role of tumor necrosis factor receptors in the activation of nuclear factor kB in human histiocytic lymphoma U-937 cells. J. Biol. Chem., 269(50):31424-31429, 1994.

67. Chaturvedi, M., LaPushin, R., and Aggarwal, B.B. Tumor necrosis factor and lymphotoxin: qualitative and quantitative differences in the mediation of early and late cellular responses. J Biol Chem, 269(20):14575-14583, 1994.

68. Darnay, B., Reddy, S., and Aggarwal, B.B. Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor. J. Biol. Chem. 269(32):20299-20304, 1994.

69. Darnay, B.G., Reddy, S.A.G., and Aggarwal, B.B. Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells. J. Biol. Chem. 269(31):19687-19690, 1994.

70. Zhang, L., Higuchi, M., Totpal, K., Chaturvedi, M.M., and Aggarwal, B.B. Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-induced cellular response. J. Biol. Chem. 269(14):10270-10279, 1994.

71. Reddy, S.A.G., Chaturvedi, M.M., Darnay, B.G., Chan, H., Higuchi, M., and Aggarwal, B.B. Reconstitution of NF- B activation induced by tumor necrosis factor requires membrane-associated components: comparison with pathway activated by ceramide. J. Biol. Chem. 269(41):25369-25372, 1994.

72. Higuchi, M. and Aggarwal, B.B. Differential roles of two types of the TNF receptor in TNF-induced cytotoxicity, DNA fragmentation and differentiation. J. Immunol, 152(8):4017-4025, 1994.

73. Higuchi, M. and Aggarwal, B.B. Tumor necrosis factor induces internalization of the p60 receptor and shedding of the p80 receptor. J. Immunol, 152(7):3550-3558, 1994.

74. Totpal, K., LaPushin, R., Kohno, T., Darnay, B.G., and Aggarwal, B.B. TNF and its receptor antibody agonist differ in mediation of cellular responses. J. Immunol, 153:2248-2257, 1994.

75. Zhang, L. and Aggarwal, B.B. Role of sulfhydryl groups in induction of cell surface down-modulation and shedding of extracellular domain of human TNF receptors in human histiocytic lymphoma U937 cells. J. Immunol, 153:3745-3754, 1994.

76. Aggarwal, B.B. and Pandita, R. Both type I and type II interferons down-regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line HEP G2: role of protein kinase C. FEBS Lett, 337:99-102, 1994.

77. Aggarwal, B.B., Pocsik, E., Ali-Osman, F., and Totpal, K. Transfection of cells with transforming growth factor- leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. FEBS Lett. 354:12-16, 1994.

78. Aggarwal, B.B., Totpal, K., Ali-Osman, F., Budde, R., and Pocsik, E. pp60v-src kinase overexpression leads to the cellular resistance to the antiproliferative effects of tumor necrosis factor. FEBS Lett. 345:219-224, 1994.

79. Chaturvedi, M., Higuchi, M., and Aggarwal, B.B. Effect of tumor necrosis factors, interferons, interleukins and growth factors on the activation of NF- B: evidence for lack of correlation with cell proliferation. Lymphokine Cytokine Res, 13(5):309-314, 1994.

80. LaPushin, R., Totpal, K., Higuchi, M., and Aggarwal, B.B. Suramin inhibits tumor cell cytotoxicity mediated through natural killer cells, lymphokine-activated killer cells, monocytes, and tumor necrosis factor. J. Clin .Immunol. 14(1):39-49, 1994.

81. Mehta, K., McQueen, T., Tucker, S., Pandita, R., and Aggarwal, B.B. Inhibition of tumor necrosis factor and nitric oxide production by all trans-retinoic acid from peritoneal macrophages. J. Leukocyte Biol, 55:336-342, 1994.

82. Pocsik, E., Mihalik, R., Ali-Osman, F., and Aggarwal, B.B. Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response. J. Cell. Biochem, 54(4):453-464, 1994.

83. Reddy, S. and Aggarwal, B.B. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett, 341(1):19-22, 1994.

84. Aggarwal, B.B., Gadhia, P.K., Hopwood, V.L., Dave, B.J., Risin, S., Owen-Schaub, L., Pandita, R., and Pathak, S. Induction of chromosomal rearrangement by tumor necrosis factors produced by primary B-lymphoblastoid cells derived from cancer patients. Lymphokine Cytokine Res, 12(1):9-19, 1993.

85. Aggarwal, B.B., Graff, K., Samal, B., Higuchi, M., and Liao, W. Regulation of two forms of the TNF receptors by phorbol ester and dibutyryl cyclic adenosine 3',5'-monophosphate in human histiocytic lymphoma cell line U-937. Lymphokine Cytokine Res, 12(3):149-158, 1993.

86. Estrov, Z., Kurzrock, R., Pocsik, E., Pathak, S., Kantarjian, H.M., Zipf, T.F., Harris, D., Talpaz, M., and Aggarwal, B.B. Lymphotoxin is an autocrine growth factor for Epstein-Barr virus (EBV)- infected B- cell lines. J. Exp. Med, 177:763-774, 1993.

87. Higuchi, M. and Aggarwal, B.B. Okadaic acid induces downmodulation and shedding of tumor necrosis factor receptors: Comparison with another tumor promoter, phorbol ester. J. Biol. Chem. 268(8):5624-5631, 1993.

88. Higuchi, M. and Aggarwal, B.B. P80 form of the human tumor necrosis factor receptor is involved in DNA fragmentation. FEBS Lett, 331(3):252-255, 1993.

89. Clark, I.A., Gray, K.M., Rockett, E.J., Cowden, W.B., Rockett, K.A., Ferrante, A., and Aggarwal, B.B. Increased lymphotoxin in human malarial serum and the ability of this cytokine to increase plasma IL-6 and cause hypoglycaemia in mice: implications for malarial pathology. Trans R Soc Trop Med Hyg, 86:602-607, 1992.

90. Fernandez, A., Chen, P.W., Aggarwal, B.B., and Ananthaswamy, H.N. Resistance of Ha-ras oncogene-induced progressor tumor variants to tumor necrosis factor and interferon- . Lymphokine Cytokine Res, 11(2):79-85, 1992.

91. Higuchi, M. and Aggarwal, B.B. Inhibition of ligand binding and antiproliferative effects of tumor necrosis factor and lymphotoxin by soluble forms of recombinant p60 and p80 receptors. Biochem. Biophys. Res. Commun. 182(2):638-643, 1992.

92. Higuchi, M. and Aggarwal, B.B. Modulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies. J. Biol. Chem, 267(29):20892-20899, 1992.

93. Higuchi, M. and Aggarwal, B.B. Microtiter plate radioreceptor assay for tumor necrosis factor and its receptors in large numbers of samples. Anal. Biochem, 204(1):53-58, 1992.

94. Ionnides, C.G., Fisk, B., Tomasovic, B., Pandita, R., Aggarwal, B.B., and Freedman, R.S. Induction of IL-2 receptor by TNF- on cultured ovarian tumor associated lymphocytes. Cancer Immunol. and Immunoth., 35(2):83-91, 1992.

95. Pandita, R., Pocsik, E., and Aggarwal, B.B. Interferon- induces cell surface expression for both types of tumor necrosis factor receptors. FEBS Lett, 312(1):87-90, 1992.

96. Pocsik, E., Higuchi, M., and Aggarwal, B.B. Down-modulation of cell surface expression of p80 form of the tumor necrosis factor receptor by human immunodeficiency virus-1 tat gene. Lymphokine Cytokine Res, 11(6):317-325, 1992.

97. Puri, R.K. and Aggarwal, B.B. HIV-1 tat gene upregulates interleukin-4 receptors on a human B-lymphoblastoid cell line. Cancer Res, 52(13):3787-3790, 1992.

98. Rockett, K.A., Awburn, M.M., Aggarwal, B.B., Cow, W.B., and Clark, I.A. In vivo induction of nitrite and nitrate by TNF, LT and IL-1: Possible roles in malaria. Infect. Immun, 60(9):3725-3730, 1992.

99. Suzuki, Y.J., Aggarwal, B.B., and Packer, L. Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells. Biochem. Biophys. Res. Commun, 189(3):1709-1715, 1992.

100. Totpal, K., Agarwal, S., and Aggarwal, B.B. Phosphotase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells. Cancer Res, 52:2557-2562, 1992.

101. Aggarwal, B.B. Structure of tumor necrosis factor and its receptor. Biotherapy, 3(2):113-120, 1991.

102. Totpal, K. and Aggarwal, B.B. Interleukin-4 potentiates the anti-proliferative effects of tumor necrosis factor against different tumor cell lines. Cancer Res, 51:4266-4270, 1991.

103. Totpal, K., LaPushin, R., Honnavara, N., Ananthaswamy, H.N., and Aggarwal, B.B. In vitro selection of NIH-3T3 cells for resistance to lymphotoxin induces resistance to activated macrophages and enhances tumorigenicity in vivo. Lymphokine Cytokine Res, 10(5):359-367, 1991.

104. Veldhuis, J.D., Garmey, J.C., Urban, R.J., Demers, L.M., and Aggarwal, B.B. Ovarian actions of tumor necrosis factor (TNF) a: Pleiotropic effects of TNF- on differentiated functions of untransformed Swine Granulosa Cells. Endocrinology, 129(2):641-648, 1991.

105. Aiyer, R.A. and Aggarwal, B.B. Characterization of receptors for recombinant human tumor necrosis factor- from human placental membranes. Lymphokine Cytokine Res, 9(3):333-344, 1990.

106. Broudy, V.C., Kaushansky, K., Shoemaker, S.G., Aggarwal, B.B., and Adamson, J.W. Muramyl dipeptide induces production of hematopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor. J. Immunol, 144(10):3789-3794, 1990.

107. Desch, C.E., Dobrina, A., Aggarwal, B.B., and Harlan, J.M. Tumor necrosis factor- exhibits greater proinflammatory activity than lymphotoxin in vitro. Blood 75(10):2030-2034, 1990.

108. Sastry, K.J., Raghav, H.R., Pandita, R., Totpal, K., and Aggarwal, B.B. HIV-1 tat gene induces tumor necrosis factor- (lymphotoxin) in a human B-lymphoblastoid cell line. J. Biol. Chem, 265(33):20091-20093, 1990.

109. Hains, J.M. and Aggarwal, B.B. Characterization of recombinant human lymphotoxin (TNF- ) produced by a mammalian cell line. Arch. Biochem. Biophys, 274(2):417-425, 1989.

110. Mehta, A.R., Eessalu, T.E., and Aggarwal, B.B. Purification and characterization of early pregnancy factor from human pregnancy sera. J. Biol. Chem, 264(4):2266-2271, 1989.

111. Pillai, S., Bikle, D.D., Eessalu, T.E., Aggarwal, B.B., and Elias, P.M. Binding and biological effects of tumor necrosis factor a on cultured human neonatal foreskin keratinocytes. J. Clin. Invest, 83(3):816-821, 1989.

112. Stauber, G.B. and Aggarwal, B.B. Characterization and affinity cross linking of receptors for human recombinant lymphotoxin (TNF- ) on a human histiocytic lymphoma cell line U937. J. Biol. Chem, 264(6):3573-3576, 1989.

113. Hudziak, R.M., Lewis, G.D., Eessalu, T.E., Aggarwal, B.B., Ullrich, A., and Shepard, H.M. Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor- in NIH 3T3 cells. Proc. Natl. Acad. Sci. USA 85(14):5102-5106, 1988.

114. Kramer, S.M., Aggarwal, B.B., Eessalu, T.E., McCabe, S.M., Figari, I.S., Ferraiolo, B.L., and Palladino, M.A. Characterization of the in vitro and in vivo species preference of human and murine tumor necrosis factor- . Cancer Res, 48:920-925, 1988.

115. Rutka, J.T., Giblin, J.R., Berens, M.E., Enar, B.-S., Tokuda, K., McCulloch, J.R., Rosenblum, M.L., Eessalu, T.E., Aggarwal, B.B., and Bodell, W.J. The effects of human recombinant tumor necrosis factor on glioma derived cell lines: cellular proliferation, cytotoxicity, morphological and radioreceptor studies. Int. J. Cancer, 41(4):573-582, 1988.

116. Stauber, G.B., Aiyer, R.A., and Aggarwal, B.B. Human tumor necrosis factor receptor: purification by immunoaffinity chromatography and initial characterization. J. Biol. Chem. 263(35):19098-19104, 1988.

117. Aggarwal, B.B. and Eessalu, T.E. Effect of phorbol esters on down-regulation and redistribution of cell surface receptors for tumor necrosis factor- . J. Biol. Chem, 262(34):16450-16455, 1987.

118. Aggarwal, B.B. and Eessalu, T.E. Induction of receptors for tumor necrosis factor- by interferons is not a major mechanism for their synergistic cytotoxic response. J. Biol. Chem, 262(21):10000-10007, 1987.

119. Bringman, T.S. and Aggarwal, B.B. Monoclonal antibodies to human tumor necrosis factors and : application for affinity purification, immunoassays and as structural probes. Hybridoma, 6(5):489-507, 1987.

120. Lewis, G.D., Aggarwal, B.B., Eessalu, T.E., Sugarman, B.J., and Shepard, H.M. Modulation of the growth of transformed cells by human tumor necrosis factor- and interferon- . Cancer Res, 47:5382-5385, 1987.

121. Locksley, R.M., Heinzel, F.P., Shepard, H.M., Agosti, J., Eessalu, T.E., Aggarwal, B.B., and Harlan, J.M. Tumor necrosis factor- and - differ in their capacities to generate interleukin 1 release from human endothelial cells. J. Immunol, 139(6):1891-1895, 1987.

122. Palladino, M.A., Shalaby, M.R., Kramer, S.M., Ferraiolo, B.L., Baughman, R.A., Delco, A.B., Crase, D., Marafino, B., Aggarwal, B.B., Figari, I.S., Liggit, D., and Patton, J.S. Characterization of the antitumor activities of human tumor necrosis factor- and the comparison with other cytokines: Induction of tumor specific immunity. J. Immunol, 138(11):4023-4032, 1987.

123. Pennica, D., Kohr, W.J., Kuang, W.J., Glaister, D., Aggarwal, B.B., Chen, E.Y., and Goeddel, D. Identification of human uromodulin as the Tamm-horsfall urinary glycoprotein. Science, 236:83-88, 1987.

124. Shalaby, M.R., Palladino, M.A., Hirabayashi, S.E., Eessalu, T.E., Lewis, G.D., Shepard, H.M., and Aggarwal, B.B. Receptor binding and activation of polymorphonuclear neutrophils by tumor necrosis factor- . J. Leukocyte Biol, 41:196-204, 1987.

125. Sugarman, B.J., Lewis, G.D., Eessalu, T.E., Aggarwal, B.B., and Shepard, H.M. Effects of growth factors on the antiproliferative activity of tumor necrosis factors. Cancer Res, 47:780-786, 1987.

126. Aggarwal, B.B., Traquina, P.R., and Eessalu, T.E. Modulation of receptors and cytotoxic response of tumor necrosis factor- by various lectins. J. Biol. Chem, 261(29):13652-13656, 1986.

127. Goeddel, D.V., Aggarwal, B.B., Gray, P.W., Leung, D.W., Nedwin, G.E., Palladino, M.A., Patton, J.S., Pennica, D., Shepard, H.M., Sugarman, B.J., and Wong, G.H.W. Tumor necrosis factors: gene structure and biological activities. Cold Spring Harbor Symposia on Quantitative Biology, L1:597-609, 1986.

128. Patton, J.S., Shepard, H.M., Wilking, H., Lewis, G., Aggarwal, B.B., Eessalu, T.E., Gavin, L.A., and Grunfeld, C. Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells. Proc. Natl. Acad. Sci. U S A, 83:8313-8317, 1986.

129. Peters, P.M., Ortaldo, J.R., Shalaby, M.R., Svedersky, L.P., Nedwin, G.E., Bringman, T.S., Hass, P.E., Aggarwal, B.B., Herberman, R.B., Goeddel, D.V., and Palladino, M.A. Naural killer-sensitive targets stimulate production of TNF- but not TNF- (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes. J. Immunol, 137(8):2592-2598, 1986.

130. Shalaby, M.R., Aggarwal, B.B., Rinderknecht, E., Sverdersky, L., Finkle, B., and Palladino, M.A. "Letter to the Editor". J. Immunol, 136(6):2335-2336, 1986.

131. Aggarwal, B.B., Eessalu, T.E., and Hass, P.E. Characterization of receptors for human tumor necrosis factor and their regulation by -interferon. Nature, 318(6047):665-667, 1985.

132. Aggarwal, B.B., Henzel, W.J., Moffat, B., Kohr, W.J., and Harkins, R.N. Primary structure of human lymphotoxin derived from 1788 lymphoblastoid cell line. J. Biol. Chem, 260(4):2334-2344, 1985.

133. Aggarwal, B.B., Kohr, W.J., Hass, P.E., Moffat, B., Spencer, S.A., Henzel, W.J., Bringman, T.S., Nedwin, G.E., Goeddel, D.V., and Harkins, R.N. Human tumor necrosis factor: Production, purification and characterization. J. Biol. Chem, 260(4):2345-2354, 1985.

134. Aggarwal, B.B. and Papkoff, H. Plasma clearance and tissue uptake of native and desialylated equine gonadotropins. Domestic Animal, 2(4):173-181, 1985.

135. Hass, P.E., Hotchkiss, A., Mohler, M., and Aggarwal, B.B. Characterization of specific high affinity receptors for human tumor necrosis factor on mouse fibroblasts. J. Biol. Chem, 260(22):12214-12218, 1985.

136. Kelker, H.C., Oppenheim, J.J., Stone-Wolff, D.S., Aggarwal, B.B., Stevenson, H.C., and Vilcek, J. Characterization of human tumor necrosis factor produced by peripheral blood monocytes and its separation from lymphotoxin. Int. J. Cancer, 36:69-73, 1985.

137. Onozaki, K., Matsushima, K., Aggarwal, B.B., and Oppenheim, J.J. Human interleukin-1 is a cytocidal factor for several tumor cell lines. J. Immunol, 135(6):3962-3968, 1985.

138. Shalaby, M.R., Aggarwal, B.B., Rinderknecht, E., Svedersky, L.P., Finkle, B.S., and Palladino, M.A. Activation of human polymorphonuclear neutrophil functions by interferon- and tumor necrosis factors. J. Immunol, 135(3):2069-2073, 1985.

139. Sugarman, B.J., Aggarwal, B.B., Hass, P.E., Figari, I.S., Palladino, M.A., and Shepard, H.M. Recombinant human tumor necrosis factor- : Effects on proliferation of normal and transformed cells in vitro. Science, 230:943-945, 1985.

140. Aggarwal, B.B., Moffat, B., and Harkins, R.N. Human lymphotoxin: Production by a lymphoblastoid cell line, purification and initial characterization. J. Biol. Chem, 259(1):686-691, 1984.

141. Gray, P.W., Aggarwal, B.B., Benton, C.V., Bringman, T.S., Henzel, W.J., Jarrett, J.A., Leung, D.W., Moffat, B., Ng, P., Svedersky, L.P., Palladino, M.A., and Nedwin, G.A. Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumor necrosis activity. Nature, 312(5996):721-724, 1984.

142. Lee, S.H., Aggarwal, B.B., Rinderknecht, E., Assisi, F., and Chiu, H. The synergistic antiproliferative effect of -interferon and human lymphotoxin. J. Immunol, 133(3):1083-1086, 1984.

143. Pennica, D., Nedwin, G.E., Hayflick, J.F., Seeburg, P.H., Palladino, M.A., Kohr, W.J., Aggarwal, B.B., and Goeddel, D.V. Human tumor necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature, 312(5996):724-729, 1984.

144. Stone-Wolff, D.S., Yip, Y.K., Kelker, H., Le, J., DeStefano, D.H., Rubin, B., Rinderknecht, E., Aggarwal, B.B., and Vilcek, J. Interrelationship of human interferon- with lymphotoxin and monocyte cytotoxin. J. Exp. Med, 159:828-843, 1984.

145. Licht, P., Papkoff, H., Bona-Gallo, A., and Aggarwal, B.B. Subunits of an avian (ostrich) follicle stimulating hormone and their hybridization with subunits of mammalian gonadotropins. Gen. Comp. Endocrinol, 51:414-422, 1983.

146. Rosenfield, R.G., Aggarwal, B.B., Hintz, R.L., and Dollar, L.A. Recombinant DNA-derived methionyl human growth hormone is similar in membrane binding properties to human pituitary growth hormone. Biochem. Biophys. Res. Commun, 106(1):202-209, 1982.

147. Aggarwal, B.B. and Papkoff, H. Relationship of sialic acid residues to in vitro biological and immunological activities of equine gonadotropins. Biol. Reprod, 24:1082-1087, 1981.

148. Aggarwal, B.B. and Papkoff, H. Studies on the disappearance of equine chorionic gonadotropin from the circulation in the rat: Tissue uptake and degradation. Endocrinology, 109(4):1242-1247, 1981.

149. Aggarwal, B.B., Papkoff, H., and Licht, P. Effect of the alpha subunit of the equine LH on the FSH induced cAMP production in rat seminiferous tubule cells. Endocrinology, 108(6):2406-2408, 1981.

150. Aggarwal, B.B., Farmer, S.W., Papkoff, H., and Seidel, G.E. Biochemical properties of equine chorionic gonadotropin from two different pools of pregnant mare sera. Biol. Reprod, 23:570-576, 1980.

151. Aggarwal, B.B., Farmer, S.W., Papkoff, H., Stewart, F., and Allen, W.R. Purification and characterization of donkey chorionic gonadotropins. J. Endocrinol, 86:449-455, 1980.

152. Aggarwal, B.B., Farmer, S.W., Papkoff, H., Stewart, F., and Allen, W.R. Purification and characterization of the gonadotropin secreted by cultured horse trophoblast cells. Endocrinology, 106(6):1066-1075, 1980.

153. Aggarwal, B.B., Licht, P., Papkoff, H., and Bona Gallo, A. Interaction of equine LH with binding sites for FSH in the rat seminiferous tubule. Endocrinology, 107(3):725-731, 1980.

154. Aggarwal, B.B. and Papkoff, H. Effects of histidine modification on the biological and immunological activities of equine chorionic gonadotropin. Arch. Biochem. Biophys, 202(1):121-125, 1980.

155. Aggarwal, B.B. and Papkoff, H. Role of histidine residues in ovine lutropin: Effects on steroidogenic activity. Biochem. Biophys. Res. Commun., 89(1):169-174, 1979.

156. Licht, P., Bona Gallo, A., Aggarwal, B.B., Farmer, S.W., Castelino, J.B., and Papkoff, H. Biological and binding activities of equine pituitary gonadotropins and pregnant mare serum gonadotropin. J. Endocrinol, 83:311-322, 1979.

157. Aggarwal, B.B., Quintanilha, A.T., Cammack, R.C., and Packer, L. Damage to mitochondrial electron transport and energy coupling by visible light. Biochem. Biophys. Acta, 502:367-382, 1978.

158. Packer, L., Aggarwal, B.B., Quintanilha, A.T., and Mehlhorn, R. Oxidative damage by environmental factors: Studies on human cells and mitochondrial membranes. Lawrence Berkeley Laboratory Annual Report, 183-186, 1977.

159. Aggarwal, B.B., Avi-Dor, Y., Tinberg, H.M., and Packer, L. Effect of visible light on the mitochondrial inner membrane. Biochem. Biophys. Res. Commun., 69(2):362-368, 1976.

160. Aggarwal, B.B., Chainy, G.B.N., Kapur, R., Kashyap, V.K., Prasad, V., Rao, S.S., and Singh, S.N. Some observations on the inhibitory effect of epinephrine on cholinesterase in the brain and muscle of some Indian fresh water fish. Comp. Physiol. Ecol, 1(2):63-66, 1976.

161. Packer, L., Fuehr, K., Walton, J., Aggarwal, B.B., and Avi-Dor, Y. Effects of visible light and oxygen on human diploid cells and mammalian mitochondria. Lawrence Berkeley Laboratory Annual Report, 1976.

162. Sun, A., Aggarwal, B.B., and Packer, L. Enzyme levels of normal human cells: Aging in culture. Arch. Biochem. Biophys. 170: 1-11, 1975.

163. Shrivastava A., Aggarwal B. B. Cytokines As Biological Regulators of Homeostasis, J. Biol.Regulators and Homeostatic Agents, 12, 1-24, 1998.

164. Singh A., Ni J. and Aggarwal, B. B Death Domain Receptors and Their Role in Cell Demise J. Interferon and Cytokine Research 18, 439-450, 1998

165. Kumar A. and Aggarwal, B.B. , Assay for redox sensitive kinases. In: Methods in Enzymology, Vol. 300 (ed. L. Packer), Academic Press, pp. 339-345, 1999.

166. Aggarwal B. B. and Higuchi H., Role of Ceramide in TNF-Mediated Apoptosis and NF- B Activation Biochem. Soc.Trans. 25 (1997), 1166-1171.

167. Darnay B. G. and Aggarwal B. B. Early Events in TNF Signaling: A Story of Associations and Dissociations. J. Leukocyte Biol. 61 (5):559-566, 1997.

168. McLain K., Estrov Z., Raju U., Kelley P. K. and Aggarwal, B. B. Epstein-barr virus EBNA-2 gene expression enhances lymphotoxin production by B-lymphocytes. Methods : A companion to Methods in Enzymology 11: 83-87, 1997.

169. Aggarwal, B.B. and Natarajan K. Tumor necrosis factors: Developments during last decade. European Cytokine Network, 7:93-124, 1996.

170. Naz, R.K., Chaturvedi, M., and Aggarwal, B.B. Role of cytokines and proto-oncogenes in sperm cell function: relevance to immunologic infertility. Am. J. Reproductive Immunol. 32:26-37, 1994.

171. Aggarwal, B.B. and Pocsik, E. Cytokines: from clone to clinic. Arch. Biochemi.Biophysi. 292(2):335-359, 1992.

172. Aggarwal, B.B. Development of new biologics: Views of the future. Cancer Bulletin, 43(2):163-168, 1991.

173. Aggarwal, B.B. Tumor necrosis factors: TNF- and TNF- their structure and pleiotropic biological effects. Drugs of the Future, 12(9): 891-898, 1987.

174. Aggarwal, B.B. Recent developments in the chemistry and biology of human lymphotoxin. Clin. Immunol. Newsletter, 6: 121-124, 1985.

175. Aggarwal B.B. Haridas V. and Chainy G. B. N. Role of two types of TNF receptors in activation of nuclear factor NF- B, C-Jun N-terminal kinase and apoptosis in Proceeding of the 10th International Congress of Immunology (ed. By Talwar GP, Nath I, Ganguly NK, Rao KVS) Monduzzi Press, Bologna Italy . Vol 1, 493-497, 1998.

176. Haridas V. and Aggarwal B. B. The expanding world of novel cytokines in Human Cytokines: A Handbook for Basic and Clinical Researchers Vol. III (eds. Aggarwal B. B.) Blackwell Scientific Publication pp. 539-556, 1997.

177. Raju U. and Aggarwal B. B. Other Novel Cytokines and Cytokine-Related Ligands in Human Cytokines: A Handbook for Basic and Clinical Researchers Vol. II (eds. Aggarwal B. B. and Gutterman J.) Blackwell Scientific Publication pp. 489-515, 1996.

178. Aggarwal B.B. and Puri R. (1995) Modulation of cytokines and their receptors by human immunodeficiency virus-1 tat gene. in Research in HIV and Cytokines (ed. M. Guenounou); INSERM Press pp. 43-48, 1997.

179. Mehta K., and Aggarwal B. B. (1998) Recombinant organisms as sources for cancer therapeutics. in Principles of Cancer Therapy (eds. R.K. Oldham) Kluwer Acad. Press, 51-57.

180. Aggarwal, B.B. and Mehta, K. Determination and regulation of nitric oxide production from macrophages by lipopolysaccharides, cytokines and retinoids. In: Methods in Enzymology, Vol. 269 (ed. L. Packer), Academic Press, pp. 166-171, 1996.

181. Aggarwal, B.B. and Singh, S. Lymphotoxin: developments during the last decade. In: Growth Factor and Cytokines in Health and Disease. Vol 2B, (edited by D. LeRoith and C. Bondy), JAI Press Inc, 727-775, 1997.

182. Darnay, B. and Aggarwal, B.B. Human Cytokines. In: Advances in Oncobiology, Vol 1, (edited by E.E. Bittar and N. Bittar), JAI Press, pp. 179-205, 1996.

183. Liao, W.S.L. and Aggarwal, B.B. Tumor necrosis factor and its inhibitors. In: Handbook of Biological Response Modifiers. (edited by M. Guenounou), Academic Press, pp. 233-250, 1995.

184. Aggarwal, B.B. and Puri, R.K. Common and uncommon features of cytokines and cytokine receptors: an overview. In: Human Cytokines: Their Role in Disease and Therapy. (edited by B.B. Aggarwal and R.K. Puri), Blackwell Science, Boston. pp. 3-24, 1994.

185. Aggarwal, B.B. and Reddy, S. Tumor necrosis factor (TNF). In: Guidebook to Cytokines and Their Receptors. (edited by N.A. Nicola), Sambrook and Tooze, pp. 103-104, 1994.

186. Aggarwal, B.B. and Reddy, S. Tumor necrosis factor receptor. In: Guidebook to Cytokines and Their Receptors. (edited by N.A. Nicola), Sambrook and Tooze, pp. 109-110, 1994.

187. Aggarwal, B.B. and Totpal, K. Mechanisms of regulation of cell growth by cytokines of the immune system. In: Oxidative Stress, Cell Activation and Viral Infection. (edited by C. Pasquier, R.Y. Olivier, C. Auclair, and L. Packer), Birkhauser Verlag, Basel. pp. 155-164, 1994.

188. Aggarwal, B.B., Totpal, K., Pocsik, E., Graff, K., Liao, W., and Higuchi, M. Role of protein kinases and phosphatases in receptor biosynthesis, shedding and mediation of cellular responses to tumor necrosis factor. In: Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (edited by W. Fiers and W.A. Buurman), Karger, Basel, Switzerland. pp. 76-80, 1993.

189. Aggarwal, B.B. Tumor necrosis factor. In: Human Cytokines: Handbook for Basic and Clinical Researchers. (edited by J.U. Gutterman and B.B. Aggarwal), Blackwell Scientific Publications, Inc., Boston. pp. 270-285, 1992.

190. Aggarwal, B.B. Lymphotoxin. In: Human Cytokines: Handbook for Basic and Clinical Researchers. (edited by J.U. Gutterman and B.B. Aggarwal), Blackwell Scientific Publications, Inc., Boston. pp. 288-298, 1992.

191. Aggarwal, B.B. Comparative analysis of the structure and function of TNF- and TNF- . In: Tumor Necrosis Factors: Structure, Function and Mechanism of Action. (edited by J. Vilcek and B.B. Aggarwal), Marcel Dekker, Inc., New York. pp. 61-78, 1992.

192. Aggarwal, B.B. and Gutterman, J.U. Other cytokines. In: Human Cytokines: Handbook for Basic and Clinical Researchers. (edited by B.B. Aggarwal and J.U. Gutterman), Blackwell Scientific Publications, Inc., Boston. pp. 418-435, 1992.

193. Aggarwal, B.B. and Totpal, K. Synergistic antiproliferative effects of TNF and IL-4 against various tumor cell lines. In: Tumor Necrosis Factor: Structure-Function Relationship and Clinical Application. (edited by T. Osawa and B. Bonavida), Krager, Basel. pp. 191-196, 1992.

194. Rege, A.A., Huang, K., and Aggarwal, B.B. Tumour necrosis factor. In: Cytokine Therapy. (edited by D.W. Galvani and J.C. Cawley), Cambridge Press, London. pp. 152-156, 1992.

195. Aggarwal, B.B. Molecular and biological characteristics of human tumor necrosis factors. In: Proceedings of the TNF Symposium: International Congress of Cancer. (edited by J. Jeekel), Springer-Verlang, Hamburg, 1991.

196. Aggarwal, B.B. Differences in the biological responses and the structure of lymphotoxin and tumor necrosis factor. In: Tumor Necrosis Factor: Structure, Mechanism of Action, Role in Disease and Therapy. (edited by B. Bonavida), S. Karger AG, Basel, Switzerland. pp. 49-54, 1990.

197. Aggarwal, B.B. Lymphotoxin and tumor necrosis factor: qualitative and quantitative differences in their receptors and signal transduction in various cell types. In: Cytokines and Lipocortins in Inflammation and Differentiation. (edited by L. Parente), Alan R. Liss, Inc., New York. pp. 375-384, 1990.

198. Stauber, G.B. and Aggarwal, B.B. Tumor necrosis factor and lymphotoxin are multipotential cytokines. In: Highlights of Modern Biochemistry. (edited by A. Kotyk), Vol. 2, pp. 1247-1254, 1989.

199. Aiyer, R.A. and Aggarwal, B.B. Tumor necrosis factors. In: CRC Handbook on Cytolytic Lymphocytes and Complement: Effectors of the Immune System. (edited by E.R. Podack), CRC Press, Inc., Boca Raton. pp. 105-132, 1988.

200. Aggarwal, B.B. Micropurification of cytokines. In: Cetus-UCLA Symposium on Protein Purification: Micro to Macro. (edited by R. Burgess), Alan R. Liss, Inc., New York. pp. 17-26, 1987.

201. Aggarwal, B.B., Aiyer, R.A., Pennica, D., Gray, P.W., and Goeddel, D.V. Human tumor necrosis factors: structure and receptor interactions. In: CIBA Foundation Symposium on Tumor Necrosis Factor and Related Cytotoxins. John Wiley & Sons, New York. pp. 39-51, 1987.

202. Aggarwal, B.B. and Bringman, T.S. Production and purification of lymphokines and their monoclonal antibodies. In: Monoclonal Antibody Production Techniques and Applications. (edited by L.B. Schook), Marcel Dekker, New York. pp. 173-187, 1987.

203. Aggarwal, B.B. and Eessalu, T.E. Human tumor necrosis factor and lymphotoxin: their structural and functional similarities. In: Cetus-UCLA Symposium on Membrane-Mediated Cytotoxicity. (edited by B. Bonavida and R. Collier), Alan R. Liss, Inc., Park City, Utah. pp. 297-307, 1987.

204. Aggarwal, B.B. Human lymphotoxin. In: Methods in Enzymology. (edited by G. DiSabato), Academic Press, New York. pp. 441-448, 1985.

205. Aggarwal, B.B., Hass, P.E., Kohr, W.J., Nedwin, G.E., Gray, P.W., Pennica, D., Svedersky, L.P., Lee, S.H., Palladino, M.A., and Goeddel, D.V. Human tumor necrosis factor - and : their biochemical and biological properties. In: Recent Advances in Chemotherapy: Anticancer section. (edited by J. Ishigami), University of Tokyo Press, Tokyo. pp. 83-85, 1985.

206. Aggarwal, B.B. and Kohr, W.H. Human tumor necrosis factor. In: Methods in Enzymology. (edited by G. DiSabato), pp. 448-456, 1985.

207. Aggarwal, B.B., Kohr, W.J., Henzel, W.J., Moffat, B., and Hass, P.E. Comparative biochemistry of human lymphotoxin and tumor necrosis factor. In: Cellular and Molecular Biology of Lymphokines. (edited by C. Sorg), Academic Press, New York. pp. 665-673, 1985.

208. Kelker, H.C., Oppenheim, J.J., Stone-Wolff, D.S., Henriksen-DeStefano, D., Vilcek, J., Stevenson, H.C., and Aggarwal, B.B. Human lymphotoxin and tumor necrosis factor: Separation and characterization of the two cytotoxins from peripheral blood leukocytes. In: Cellular and Molecular Biology of Lymphokines. (edited by C. Sorg), Academic Press, New York. pp. 341-347, 1985.

209. Aggarwal, B.B., Moffat, B., Lee, S.H., and Harkins, R.N. Chemical and biological properties of human lymphotoxin. In: Thymic Hormones and Lymphokine. (edited by A.L. Goldstein), Plenum Publishing Corporation, New York. pp. 235-245, 1984.

210. Aggarwal, B.B., Moffat, B., and Harkins, R.N. Purification and characterization of lymphotoxin from human lymphoblastoid cell line 1788. In: Interleukins, Lymphokines and Cytokines. (edited by J.J. Oppenheim, S. Cohen, and M. Landy), Academic Press, New York. pp. 521-526, 1983.

211. Papkoff, H. and Aggarwal, B.B. Role of histidine in ovine luteinizing hormone and equine chorionic gonadotropins. In: Serono Symposium. Academic Press, London and New York, San Marino, Italy. pp. 11-19, 1982.

1. Aggarwal, B.B. (ed.) Human Cytokines: A Handbook for Basic and Clinical Research, Volume III. Blackwell Science Publication, Inc., Boston, pp. 1-640, 1997.

2. Aggarwal, B.B. and Gutterman, J.U. (eds.) Human Cytokines: A Handbook for Basic and Clinical Research, Volume II. Blackwell Science Publication, Inc., Boston, pp. 1-526, 1996.

3. Aggarwal, B.B. and Puri, R.K. (eds.) Human Cytokines: Their Role in Disease and Therapy. Blackwell Science, Boston, pp. 1-736, 1995.

4. Aggarwal, B.B. and Vilcek, J. (eds.) Tumor Necrosis Factor: Structure, Function and Mechanism of Action. Marcel Dekker, New York, pp. 1-600, 1992.

5. Aggarwal, B.B. and Gutterman, J.U. (eds.) Human Cytokines: A Handbook for Basic and Clinical Research, Volume I Blackwell Science Publications, Inc., Boston, pp. 1-464, 1992.

6. Aggarwal, B.B. (Guest editor) Special Issue on Tumor Necrosis Factor, Biotherapy. Vol. 3, No. 2, Kluwer Academic Publishers, 1991.

1. Aggarwal, B.B. (ed.) Human Cytokines: A Handbook for Basic and Clinical Researchers, Volume III. Blackwell Science Publications, Inc., Boston, pp. 1-640, 1997.

2. Aggarwal, B.B. and Gutterman, J.U. (eds.) Human Cytokines: A Handbook for Basic and Clinical Researchers, Volume II. Blackwell Science Publications, Inc., Boston, pp. 1-526, 1996.

3. Aggarwal, B.B. and Puri, R.K. (eds.) Human Cytokines: Their Role in Disease and Therapy. Blackwell Science, Boston, pp. 1-736, 1995.

4. Aggarwal, B.B. and Vilcek, J. (eds.) Tumor Necrosis Factor: Structure, Function and Mechanism of Action. Marcel Dekker, New York, pp. 1-600, 1992.

5. Aggarwal, B.B. and Gutterman, J.U. (eds.) Human Cytokines: A Handbook for Basic and Clinical Researchers. Volume I. Blackwell Science Publications, Inc., Boston, pp. 1-464, 1992.

1. Uses of TRANK, a Novel Secretory Cytokine. Aggarwal, B.B. Provisional Patent No. D6131, date 8/18/98.

2. Uses of THANK a TNF homologue that activates apoptosis (D-6206) Aggarwal, B. B., as inventor (s). filed 2/ 2/99

3. Inhibition of nuclear transcription factor NF- B by caffeic acid phenethyl ester (CAPE), derivatives of CAPE, capsaicin (8-methyl-N-vanillyl-6-nonenamide) and Resiniferatoxin. Aggarwal, B. B., Burke Jr. T.R., and Grunberger D, as inventor (s). International Publication No. WO 98/09620, date 3/12/98.

4. Curcumin (diferuloylmethane) inhibition of NF- B activation. Aggarwal, B. B., as inventor (s). US Patent No. 5,891,924 , issue date 4/6/99. International Publication No. WO 97/09877, date 3/20/97.

5. Novel Antiproliferative Protein from Bacillus thuringiensis var.thuringiensis. Aggarwal, B. B. and C. R. Padilla, as inventor(s). International Publication No. WO 96/38477, date 12/5/96; US Patent No. 5,824,636 , issue date 10/20/98.

6. Protein phosphatase inhibition of tumor necrosis factor effects and NF-kB activation. Aggarwal, B. B. as inventor(s). Patent Number: PCT/US95/15757, 12/5/95.

7. Tumor necrosis factor antagonists and their use. Aggarwal, B.B. and Shalaby, R. as inventor(s). Patent Number: pending.

8. Tumor necrosis factor receptor-1 associated protein kinase and methods for its use. Aggarwal, B.B. and Darnay, B.G. as inventor(s). Patent Number: 5,856,161; Issue date 1/5/99.

9. Inhibition of TNF by retinoic acid. Aggarwal, B.B. as inventor(s). Patent Number: 061,471 (EP); 5,658,949 (US), 8/19/97.

10. Tumor necrosis factor receptor-II-associated protein kinase and methods for its use. Aggarwal, B.B. and Darnay, B.G. as inventor(s). Patent Number: 08/588,604 (USSN); 5,837,817 (US), issue date 11/17/98.

11. Cytokine regulation of cellular senescence. Aggarwal, B.B. as inventor(s). International Publication No. WO 96/05850, date 2/29/96.

12. Curcumin, analogues of curcumin and novel uses thereof. Aggarwal, B.B. as inventor(s). International Publication No. WO95/18606, date 7/13/95.

13. Uses of triplex forming oligonucleotides for the treatment of human diseases. Aggarwal, B.B., Rando, R.F., and Logan, M.E. as inventor(s). Patent Number: WO 95/33493. 5,650,316 (US), issue date 7/22/97.

14. Inhibition of TNF nitric oxide production by retinoic acid. Aggarwal, B.B. and K. Mehta as inventor(s). Patent Number: 061,471 (EP); 5,457,129 (US), issue date 10/10/95.

15. A novel anti-neoplastic cytokine. Aggarwal, B.B. as inventor(s). US Patent Number: 5,241,051, issue date 8/31/93.

16. Synergism of tumor necrosis factor and interleukin-4. Aggarwal, B.B. as inventor(s). International Publication No. W092/05805, date 4/16/92. Patent Number: 038,038.

17. Protein structure of the plant toxin gelonin. Aggarwal, B.B., Rosenblum, M., and Kohr, W.J. as inventor(s). U. S. Patent No. 5,631,348, issue date 5/20/97.

18. Human Lymphotoxin. Aggarwal, B.B. as inventor(s). Patent Number: (US) 4,920,196, issue date 4/24/90; (EP) 01,100,641 date 2/15/84.

19. Synergistic composition comprising gamma interferon and lymphotoxin, and its preparation. Aggarwal, B.B. and Lee, S.H. as inventor(s). Patent Number: 0,128,009 (EP), date 12/12/84.

20. Synergistic cytotoxic composition. Aggarwal, B.B. and Lee, S.H. as inventor(s). Patent Number: 4,650,674, date 3/17/87.

21. Lymphotoxin, nucleic acid encoding it, vectors incorporating the nucleic acid and cells transformed therewith, methods of obtaining lymphotoxin and lymphotoxin neutralizing antibody. Aggarwal, B.B., Gray, P., Bringman, T.S., and Nedwin, G. as inventor(s). Patent Number: 0,164,965 (EP), 12/18/85.

22. Tumor necrosis factor, methods for its preparation, compositions containing it, DNA encoding it and assay method using such DNA. Aggarwal, B.B., Lee, S.H., Goeddel, D., and Nedwin, G. as inventor(s). Patent Number: 0,168,214 (EP), date 1/15/86.

1998      Guest Lecturer: Graduate Biochemistry, UTGSBS

1997      Invited Speaker: Long Distance Learning Program UT-GSBS

1996      Invited speaker: Pharmacology Graduate Seminar UT Medical School

1994 - 1995      Molecular Biology of Oncogenes, UTGSBS

1984 - 1988      Instructor Medical Virology / Microbiology Duke University                          Medical Center

1980      Instructor Medical Virology/Microbiology University of Virginia Medical               Center

1975 - 1979      Teaching Assistant
                         Department of Microbiology
                         University of Maryland
                         General Microbiology, Virology, Graduate Virology, and
                         Graduate Genetics