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Genetics

  • cDNA xProfiler
    • The cDNA xProfiler is a tool that compares gene expression between two pools of libraries. For a gene to be "present" in a library pool, there must be at least one EST sequence found in the UniGene cluster for that gene.
  • DGED: Digital Gene Expression Displayer
    • The Digital Gene Expression Displayer is a tool that compares gene expression between two pools of libraries. In contrast to the xProfiler, the DGED treats the presence of a gene in a library pool as a matter of degree. It compares the "degree" of presence of a gene in pool A with its "degree" of presence in pool B.
  • FISH-mapped BACs
    • CGAP is generating a set of Bacterial Artificial Chromosome (BAC) clones (available to the public) that have been mapped cytogenetically by fluorescence in situ hybridization (FISH) and physically by sequence tagged sites (STSs) to the human genome. The BAC data is integrated into various CGAP and NCBI databases to provide related clinical, histopathologic, genetic, and genomic information.
  • GenBank - NIH
    • Updated monthly. GenBank®, the NIH genetic sequence database, is an annotated collection of all publicly available DNA sequences. There are approximately 20,649,000,000 bases in 17,471,000 sequence records as of June 2002.
  • Gene Finder
    • The Gene Finder tool finds one gene or list of genes, based on selected search criteria. Each "found" gene is linked to a Gene Info page which provides selected gene data and links to various NCBI and NCI databases.
  • GeneMap99
    • A new human gene map from the International RH Mapping Consortium. Each chromosome is displayed with RH Map GB3 and GB4, the genetic map, gene density and a cytogenetic ideogram.
  • GLS: Gene Library Summarizer
    • The GLS Tool finds all the genes expressed in a single cDNA library or group of cDNA libraries. It then classifies the genes as unique or non-unique, and then further identifies the genes in each of these groups as known or unknown.
  • GO Browser
    • The Genetic Ontology Browser classifies human and mouse genes by molecular function, biological process, and cellular component. This database is best viewed in Internet Explorer and must be accessed from the outlink page that you are taken to.
  • IARC TP53 Mutation Database
    • This database is made up of 3 parts, the Somatic Mutation Database, the Germline Mutation Database and a List of Common Polymorphisms. The Somatic Mutation Database contains exclusively p53 mutations associated with human cancers that have been identified by sequencing and published in the peer-reviewed literature. The Germline Mutation Database contains information on families fulfilling the definition of Li Fraumeni and Li Fraumeni-related syndromes and on individuals carrying a germline mutation in the TP53 gene. The list of polymorphisms is a simple table that describes the DNA sequence variants (polymorphisms) that have been observed in the human population.
  • Library Finder
    • The Library Finder tool can find a single cDNA or SAGE library or a group of libraries, depending on the search criteria selected. The search first returns a Library List page, from which each library is linked to its own Library Info page. This page contains sequence and clone information and details of the library's preparation.
  • Mitelman Database of Chromosome Aberrations in Cancer
    • The information in the Mitelman Database of Chromosome Aberrations in Cancer relates chromosomal aberrations to tumor characteristics, based either on individual cases or associations. The Cancer Genome Anatomy Project has developed 5 tools to help with analysis of information in this database.
  • Mouse Models of Human Cancer (MMHC)
    • The Mouse Models of Human Cancer database can be queried for models submitted by fellow researchers. Information about the making of models, their genetic description, histopathology, derived cell lines, associated images, carcinogenic agents, and therapeutic trials can be retrieved. Links to associated publications and other resources are provided.
  • Nucleotide BLAST
    • The Basic Local Alignment Search Tool (BLAST) is a set of specialized search programs which find similarities between either protein or nucleotide sequences. Here, CGAP provides an alternative interface to this tool to specifically ask whether a DNA sequence is similar to any UniGene clusters. If a gene similarity is found, a link to the Gene Info page is provided.
  • Oncomine - (Provided by Research IS & Technology Services)
    • With Oncomine Research Premium Edition, users have access to advanced analyses including biomarker and mutation status, primary vs. metastatic comparisons, recurrence and drug sensitivity as well as export functionality and custom concept upload for comparison across all other Oncomine datasets. We also release new data every quarter to Oncomine Research Premium Edition while new data is added to Oncomine Research Edition once per year.
  • Online Mendelian Inheritance in Man (OMIM)
    • OMIM is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries contain copious links to other genetics resources.
  • SNP Gene Viewer
    • The Gene Viewer is a graphical display tool. Both CGAP SNPs and SNPs submitted to the NCBI dbSNP database by other investigators are shown in the context of transcripts, open reading frames and protein motifs.
  • SNP500 Cancer
    • The goal of the SNP500Cancer project is to resequence 102 reference samples to find known or newly discovered single nucleotide polymorphisms (SNPs) which are of immediate importance to molecular epidemiology studies in cancer. SNP500Cancer provides a central resource for sequence verification of SNPs.

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