Cancer Biology	Developmental Biology	Gene Regulation	Structural Biology	Cell Growth & Signaling	Proteomics & Genomics

Cancer Biology Genes and processes that affect cancer development.

Michelle Barton, Ph.D.	Chromatin; transcription; p53 tumor suppressor; embryonic stem cells
Richard R. Behringer, Ph.D.	Mammalian embryogenesis; pattern formation; reproductive biology and disease; transgenic and knockout mice
Sandy Chang, M.D., Ph.D.	Telomere dysfunction; genomic instability and cancer; molecular biology of aging; molecular cytogenetics analysis of carcinomas; mouse models of aging and cancer
Sharon Roth Dent, Ph.D.	Histone modifications; gene regulation; genome stability; cancer epigenetics
Elsa R. Flores, Ph.D.	Mouse models; tumor suppressor genes; metastasis; cell cycle; apoptosis
Maria-Magdalena Georgescu, M.D., Ph.D.	Molecular mechanisms of cancer cell proliferation and metastasis; PTEN tumor suppressor; mouse models
Vicki Huff, Ph.D.	Human genetics; cancer genetics; familial cancer predisposition; kidney development
Ann Killary, Ph.D.	Tumor suppressor genes; gene discovery; breast and pancreatic cancer genetics
Ralf Krahe, Ph.D.	Human and molecular genetics; neurogenetics; cancer genetics; genomics
Mong-Hong Lee, Ph.D.	Cell cycle regulation; cyclin-dependent kinase inhibitors and tumorigenesis; gene knock out; signal transduction
Randy Legerski, Ph.D.	Mechanisms of DNA repair; recombinational repair; stress-induced cell cycle checkpoint responses
Guillermina (Gigi) Lozano, Ph.D.	Tumor suppressors; mouse models; apoptosis
Sadhan Majumder, Ph.D.	Stem cells; neuroregeneration; neural tumors; transcriptional regulation; chromatin; mouse models
Angabin Matin, Ph.D.	Germ cell tumors; biology of germ cells; genetic dissection of disease susceptibility; mouse models
Lalitha Nagarajan, Ph.D.	Genetic regulation; chromosomal alterations; malignant transformation; hematopoiesis
Michael J. Siciliano, Ph.D.	Cancer genetics; mutation; mismatch repair; genome instability
Shinako Takada, Ph.D.	Mechanisms of transcriptional regulation; in vitro transcription; TATA-less promoters; TBP-related factors

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Developmental Biology Studies on how cells differentiate and form complex tissues or organ systems.

Richard R. Behringer, Ph.D.	Mammalian embryogenesis; pattern formation; reproductive biology and disease; transgenic and knockout mice
Andreas Bergmann, Ph.D.	Genetic control of programmed cell death; apoptosis; cell survival; growth control; signal transduction
Benoit de Crombrugghe, M.D.	Cell fate determination; cell differentiation; chondrocytes; osteoblasts
Yasuhide Furuta, Ph.D.	Organogenesis; inductive tissue interactions; secreted signaling molecules; mouse molecular genetics
Georg Halder, Ph.D.	Growth control; regeneration; tumor suppressor genes; Drosophila genetics
Randy L. Johnson, Ph.D.	Mouse genetics; pattern formation; development; gene targeting
William H. Klein, Ph.D.	Embryo development; transcription factors in development; control of gene expression; cell fate specification and differentiation; gene regulatory networks
Sadhan Majumder, Ph.D.	Stem cells; neuroregeneration; neural tumors; transcriptional regulation; chromatin; mouse models
James F. Martin, M.D., Ph.D.	Left-right asymmetry; cardiac development; mouse genetics; homeobox genes
William Mattox, Ph.D.	Regulation of RNA splicing; sex determination; muscular dystrophy
Pierre D. McCrea, Ph.D.	Catenin biology; development; intracellular and nuclear signaling; Xenopus laevis (frog embryo) and mammalian cell systems
Jill Schumacher, Ph.D.	Microtubules; chromosomes; mitosis; meiosis; cell cycle control; C. elegans genetics
Miles Wilkinson, Ph.D.	RNAi and miRNAs; RNA splicing and decay; germ-cell development; transcriptional regulation; transgenic and knockout mice

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Gene Regulation The mechanisms by which chromatin structure, transcription, RNA processing and translation are regulated.

Michelle Barton, Ph.D.	Chromatin; transcription; p53 tumor suppressor; embryonic stem cells
Richard G. Brennan, Ph.D.	Multidrug resistance; gene regulation; protein-ligand interaction; X-ray crystallography
Xiaomin Chen, Ph.D.	X-ray crystallography; macromolecular interactions; signal transduction; transcriptional regulation; apoptosis
Benoit de Crombrugghe, M.D.	Cell fate determination; cell differentiation; chondrocytes; osteoblasts
Sharon Roth Dent, Ph.D.	Histone modifications; gene regulation; genome stability; cancer epigenetics
Elsa R. Flores, Ph.D.	Mouse models; tumor suppressor genes; metastasis; cell cycle; apoptosis
Michael Galko, Ph.D.	Wound healing: molecular/genetic strategies to sense, contain and repair tissue damage; Drosophila genetics; cell biology
Raymond H. Jacobson, Ph.D.	X-ray crystallography; transcription; chromatin; gene expression
William H. Klein, Ph.D.	Embryo development; transcription factors in development; control of gene expression; cell fate specification and differentiation; gene regulatory networks
Warren S.-L. Liao, Ph.D.	Cytokines; signal transduction; gene expression; transcription factors; drug development
Guillermina (Gigi) Lozano, Ph.D.	Tumor suppressors; mouse models; apoptosis
Sankar N. Maity, Ph.D.	Protein biochemistry; transcription factors; cell cycle and stress
William Mattox, Ph.D.	Regulation of RNA splicing; sex determination; muscular dystrophy
Shinako Takada, Ph.D.	Mechanisms of transcriptional regulation; in vitro transcription; TATA-less promoters; TBP-related factors
Miles Wilkinson, Ph.D.	RNAi and miRNAs; RNA splicing and decay; germ-cell development; transcriptional regulation; transgenic and knockout mice

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Structural Biology Analysis of the function of macromolecules through structural determination by crystallography and other methods.

Richard G. Brennan, Ph.D.	Multidrug resistance; gene regulation; protein-ligand interaction; X-ray crystallography
Xiaomin Chen, Ph.D.	X-ray crystallography; macromolecular interactions; signal transduction; transcription regulation; apoptosis
Raymond H. Jacobson, Ph.D.	X-ray crystallography; transcription; chromatin; gene expression
Maria A. Schumacher, Ph.D.	X-ray crystallography; transcription initiation; transcription regulation; partition; DNA segregation; cell division

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Cell Growth & Signaling Studies on the mechanisms by which cells signal to one another to control their growth, shape, migration and proliferation.

Andreas Bergmann, Ph.D.	Genetic control of programmed cell death; apoptosis; cell survival; growth control; signal transduction
Sandy Chang, M.D., Ph.D.	Telomere dysfunction; genomic instability and cancer; molecular biology of aging; molecular cytogenetics analysis of carcinomas; mouse models of aging and cancer
Yasuhide Furuta, Ph.D.	Organogenesis; inductive tissue interactions; secreted signaling molecules; transgenic mice; gene targeting
Michael Galko, Ph.D.	Wound healing: molecular/genetic strategies to sense, contain and repair tissue damage; Drosophila genetics; cell biology
Maria-Magdalena Georgescu, M.D., Ph.D.	Molecular mechanisms of cancer cell proliferation and metastasis; PTEN tumor suppressor; mouse models
Howard B. Gutstein, M.D.	Proteomic approaches to addiction and opioid tolerance; interaction of pain and analgesic signal transduction mechanisms
Georg Halder, Ph.D.	Growth control; regeneration; tumor suppressor genes; Drosophila genetics
Randy L. Johnson, Ph.D.	Mouse genetics; pattern formation; development; gene targeting
Jian Kuang, Ph.D.	Cell-cycle control; signal transduction; DNA damage-induced checkpoint response
Mong-Hong Lee, Ph.D.	Cell cycle regulation; cyclin-dependent kinase inhibitors and tumorigenesis; gene knock out; signal transduction
Randy Legerski, Ph.D.	Mechanisms of DNA repair; recombinational repair; stress-induced cell cycle checkpoint responses
Warren S.-L. Liao, Ph.D.	Cytokines; signal transduction; gene expression; transcription factors; drug development
Sankar N. Maity, Ph.D.	Protein biochemistry; transcription factors; cell cycle and stress
James F. Martin, M.D., Ph.D.	Left-right asymmetry; cardiac development; mouse genetics; homeobox genes
Greg S. May, Ph.D.	Fungal genetics; cell motility; fungal pathogenesis
Pierre D. McCrea, Ph.D.	Catenin biology; development; intracellular and nuclear signaling; Xenopus laevis (frog embryo) and mammalian cell systems
Jill Schumacher, Ph.D.	Microtubules; chromosomes; mitosis; meiosis; cell cycle control; C. elegans genetics
Maria A. Schumacher, Ph.D.	X-ray crystallography; transcription initiation; transcription regulation; partition; DNA segregation; cell division

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Proteomics & Genomics Studies on the effects of disease and other biological processes on large sets of proteins or genes using microarrays and bioinformatics approaches.

Howard B. Gutstein, M.D.	Proteomic approaches to addiction and opioid tolerance; interaction of pain and analgesic signal transduction mechanisms
Ralf Krahe, Ph.D.	Human and molecular genetics; neurogenetics; cancer genetics; genomics
Greg S. May, Ph.D.	Fungal genetics; cell motility; fungal pathogenesis

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Last updated: 11/19/2007