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Li-Fraumeni Syndrome is a rare inherited disorder (germline mutations of the p53 tumor-suppressor gene have been identified in families with this syndrome) characterized by susceptibility to breast cancer, sarcomas of soft-tissue and bone, brain tumors and other neoplasms (4). In addition to a genetic predisposition other factors postulated in the etiology of soft-tissue sarcomas include trauma, burns, chemical carcinogens and radiation therapy.
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