Introduction Section 1 Section 2 Section 3 Conclusion and References

 

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Conclusion and References

Conclusion

As this exhibit demonstrates, the leukemic patient is at risk for a large variety of CNS complications. Imaging is a vital link in the work-up of these patients. A thorough familiarity with the different complications and their imaging appearance is essential in order to make the correct diagnosis and avoid a potentially harmful misdiagnosis. All pertinent clinical information such as prior and current therapy, presenting signs and symptoms, and any lab data must be considered along with the radiologic findings if an accurate evaluation is to be made in the leukemic presenting with signs of neurological disease.

References

  1. Azzarelli B, et al. Pathogenesis of central nervous system infiltration in acute leukemia. Arch Pathol Lab Med. 101:203-205, 1977.
  2. Banna M, et al. Orbital granulocytic sarcoma, AJNR 12:255-258,1991.
  3. Barnett MJ, et al. Granulocytic sarcoma of the brain: A case report and review of the literature, Radiology 160:223-225, 1986.
  4. Bleyer WA. Neurologic sequelae of methotrexate and ionizing radiation: A new classification, Cancer Treatment Reports, 65 (Supplement l):89-98, 1981.
  5. Brooks HW, et al. Chloromas of the head and neck in childhood, Arch Otolaryngol. 100:306-308, 1974
    .
  6. Carmack MA, et al. Multifocal leukoencephalitis caused by Varicella-Zoster virus in a child with leukemia: Successful treatment with Acyclovir. Pediatr Infect Dis J 12:402-406, l993.
  7. Chung CK, et al. Glioblastoma multiforme following prophylactic cranial irradiation and intrathecal methotrexate in a child with acute lymphocytic lukemia. Cancer 47:2563-2566, l981.
  8. Feinberg WM, et al. Cerebrovascular complications of L-asparaginase therapy. Neurology 38:127-133, 1988.
  9. Freireich EJ, et al. A distinctive type of intracerebral hemorrhage associ at_ed with "blastic crisis" in patients with leukemia, Cancer 13:146-154, 1960.
  10. Gay CT, et al. Reversible treatment related leukoencephalopathy, J Child Neurol 4:207-212, 1989.
  11. Gastaut J-A, et al. Computerized axial tomography in the study of intracranial complications in hematology, Cancer 41:487-501, 1978.
  12. Graus F, et al. Cerebrovascular complications in patients with cancer, Medicine 64:16-35,1985.
  13. Grisold W, et al. Necrotizing myelopathy associated with acute lymphoblastic leukemia, Acta Neuropathol (Berl) 234-235, 1980.
  14. Grossman L, et al. Central nervous system toxicity of high-dose cytosine arabinoside. Medical and Pediatric Oncology 11:246-250, 1983
  15. Kingma AK, et al. Magnetic resonance imaging of the brain and neuropsychological evaluation in children treated for acute lymphoblastic leukemia at a young age, Am J Pedia Hematol/Onco 15:231-238, 1993.
  16. Lentz D, et al. MRI in Varicella-Zoster virus leukoencephalitis in the immunocompromised host, JCAT 17:313-316, 1993.
  17. Levine GA, et al. CNS involvement as the initial manifestation of acute leukemia, Cancer 31:959-962, l973.
  18. Levy R, et al. Granulocytic sarcoma (chloroma) of the temporal bone, Internat'l J Pediac Otorhinolaryng. 18:163-169.
  19. Lockman LA, et al. Dural venous sinus thrombosis in acute lymphoblastic leukemia. Pediatrics 66: 943-947, 1980.
  20. McKinstry CS, et al. Bone marrow in leukemia and aplastic anemia: MR imaging before during and after treatment. Radiology 162:701-707, 1987.
  21. Miller L, et al. Cerebellar atrophy caused by high-dose cytosine arabinoside: CT and MR findings. AJR 152: 343-344.
  22. Moore EW, et al. The central nervous system in acute leukemia, Arch Int Med 105:451-467. 1960.
  23. Moore SG, et al. Bone marrow in children with acute lymphocytic leukemia: MR relaxation times. Radiology 160:237-240, 1986.
  24. Pagani, JJ, et al. Central nervous system leukemia and lymphoma: Computed tomographic manifestations, AJR 137:1195-1201, 1981.
  25. Pomeranz SJ, et al. Granulocytic Sarcoma (Chloroma): CT Manifestations, Radiology 155:167-170, 1985.
  26. Regelson W, et al. Incidence of second primary tumors in children with cancer and leukemia: A Seven-Year Survey of 150 consecutive autopsied cases, Cancer 18:58-72, 1965.
  27. Sowers JJ, et al. Radiographic features of Granulocytic Sarcoma (Chloroma), JCAT, 3:226-233, 1979.
  28. Stevens SK, et al. Repopulation of marrow after transplantation: MR imaging with pathologic correlation, Radiology 175:213-218, 1990.
  29. Truwit CL, et al. MR imaging of reversible Cyclosporin A-induced neurotoxicity, AJNR 12:651- 659, 1991.
  30. Viscoli C, et al. Listeria Monocytogenes brain abscesses in a girl with acute lymphoblastic leukaemia after later central nervous system relapse, Eur J Cancer 23:437-441, 1991.
  31. Wolk RW, et al. The Incidence of central nervous system leukemia in adults with acute leukemia, Cancer 35:863-869, 1974.
  32. Leukemia, 5th Edition, Eds: Henderson ES and Lister TA, W. B. Saunders, Philadelphia, 1990.

 

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