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  Bingliang Fang , M.D., Ph.D.
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Bibliography- Bingliang Fang , M.D., Ph.D.

Published and accepted articles in refereed journals:

  1. Fang, B.L., Luo, H.Y. Mucopolysaccharidoses (review). Medicine Abroad (Mol. Genet.), 4:169-172, 1984.
  2. Shi, HP., Zhang, G.X., Guo, Y.F., Fang, B.L., Zhang, W.M., Chen, F., Luo, H.Y., Laboratory diagnosis of lysosomal storage disease (Glycoproteinosis, Pompe's disease and Gaucher disease). Acta Academiae Medicinae Sinicae, 7:475-477, 1985.
  3. Fang, B.L., Guo, Y., Luo, H.Y. 35S-Sulfate incorporation in cultured normal human skin fibroblasts and amniotic fluid cells. Proc. Chin. Acad. Med. Sci. and Peking Union Med. Coll., 1:120-122, 1986.
  4. Fang, B.L., Shi, H.P, Luo, H.Y. Diagnosis and classification of mucopolysaccharidoses using 35S-Sulfate incorporation. Proc. Chin. Acad. Med. Sci. and Peking Union Med. Coll., 1:116-119, 1986.
  5. Fang, B.L., Guo, Y.F., Luo, H.Y. [35S-sulfate incorporation in cultured normal human skin fibroblasts and normal amniotic fluid cells]. Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao, 8:223-225, 1986.
  6. Fang, B.L., Shi, H.P., Luo, H.Y. Diagnosis and classification of mucopolysaccharidoses using the 35S-sulfate incorporation test. Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao, 8:226-229, 1986.
  7. Shi, H.P., Guo, Y., Fang, B.L., Chen, F., and Luo, H.Y. Activities of 7 lysosomal enzymes in chorion villi tissue. Heredity and Diseases, 5:179, 1988.
  8. Ye, L., Shi, H.P., Yuan, L., Ma, S., Fang, B., Zhao, Y., Zhao, S., Gao, C., and Luo, H.Y. Analysis of 4628 cases in the genetic counseling clinic of PUMC hospital. Proc. Chin. Acad. Med. Sci. and Peking Union Med. Coll, 4:126, 1989.
  9. Singh, S., Fritze, G., Fang, B.L., Harada, S., Paik, Y.K., Eckey, R., Agarwal, D.P, Goedde, W.H. Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korea families reveals a dominance of the mutant allele. Hum. Genet., 83:119-21, 1989.
  10. Chen, F., Huang, S.Z., Fang, B., Pan, X., Wu, Y., and Luo, H.Y. Carrier detection of Duchenne Muscular Dystrophy with restriction fragment length polymorphism (RFLP) haplotype analysis. Chinese Medical Journal, 71:339-341, 1991.
  11. Li, J., Fang, B., Liu, Y., and Luo, H.Y. Isolation of chromosomal sized human and yeast genomic DNA for pulse field electrophoresis. Chinese Journal of Medical Genetics, 8:344, 1991.
  12. Goedde, H.W., Agarwal, D.P., Fritze, G., Meier-Tckmann, D., Singh, S., Beckman, G., Bhatia, K., Chen, L., Fang, B., and Lisker, R.. Distribution of ADH2 and ALDH2 genotypes in different populations. Hum. Genet, 88:344-346, 1992.
  13. Fang, B. Restriction fragment length polymorphism (RFLP) analysis (methodology review). Basic Med. Sci. Clin, 11:376-380, 1992.
  14. Fang, B., and Luo, H.Y. Advances in molecular biology of inherited neurological diseases (review). Medicine Abroad (Mol. Genet.), 14:345, 1992.
  15. Fang, B., Wang, M., Gao, X., Huang, S.Z., and Luo, H.Y. Tightly linked DNA probe for presymptomatic diagnosis and carrier detection of Wilson disease. Chinese Medical Journal, 72:746-748, 1992.
  16. Wang, T., Yuan, L., Fang, B., Huang, S.Z., and Luo, H.Y. Prenatal diagnosis of classical phenylketonuria with polymerase chain reaction and allele specific oligonucleotide probe hybridization. Chinese Journal of Pediatrics, 34:341, 1992.
  17. Fang, B., Wang, M., Huang, S.Z., Li, J., Tang, X., and Luo, H.Y. Polymorphisms of D13S26 locus in Chinese and its application to linkage analysis in Wilson's disease. Acta Academiae Medicinae Sinicae, 14: 206-209, 1992.
  18. Fang, B., Wang, T., Yuan, L., Huang, S., Liu, Z., Wang, M., Liu, Z., and Luo, H.Y. Analysis of RFLP haplotypes and point mutations at the phenylalanine hydroxylase (PAH) locus in PKU families from North China. Acta Academiae Medicinae Sinicae, 14:46-49, 1992.
  19. Miao, S., Fang, B., Huang, S., Wang, M., Yuan, L., and Luo, H.Y. Detection of point mutations in exon 7 of phenylalanine hydroxylase gene by PCR-SSCP method. Chinese Journal of Medical Genetics, 10:1511-1514, 1993.
  20. Fang, B., and Luo, H.Y. Advances in technology of yeast artificial chromosome cloning (review). Prog. Biochem. Biophys., 10:297, 1993.
  21. Fang, B., Yuan, L., Wang, M., Huang, S.Z., Wang, T., and Luo, H.Y. Detection of point mutations of phenylalanine hydroxylase gene and prenatal diagnosis of phenylketonuria. Chinese Journal of Medical Science, 7:205-208, 1993.
  22. Kay, M.A., Landen, C.N., Rothenberg, S.R., Tarlor, L.A., Leland, F., Wiehle, S., Fang, B., Bellinger, D., Finegold, M., and Thompson, A.R. In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc. Natl. Acad. Sci., 91:2353-2357, 1994.
  23. Fang, B., Eisensmith, R.C., Li, X.H., Finegold, M.J., Shedlovsky, A., Dove, W., and Woo, S.L. Gene therapy for phenylketonuria: phenotypic correction in a genetically deficient mouse model by adenovirus-mediated hepatic gene transfer. Gene Ther., 1:247-254, 1994.
  24. Song, F., Fang, B., Liu, J., Luo, H.Y., and Wu, G. Multiplex allele specific polymerase chain reaction in the diagnosis of phenylketonuria. Chinese Sci. Bullet., 39:76-79, 1994.
  25. Fang, B., Eisensmith, R. and Woo, S.L.C. Phenylketonuria: a genetic model for gene therapy. Mental Retardation Develop. Disabil, 1:56-61, 1995.
  26. Fang, B., Eisensmith, R.C., Wang, H., Kay, M.A., Cross, R.E., Landen, C.N., Gordon, G., Bellinger, D. A., Read, M.S., Hu, P.C., Brinkhous, K.M., and Woo, S.L.C. Gene therapy for hemophilia B: host immunosuppression prolongs therapeutic effect of adenovirus-mediatedfactor IX expression. Human Gene Ther., 6:1039-1044, 1995.
  27. Li, J., Fang, B., Eisensmith, R.C., Li, X.H., Nasonkin, I., Lin-Lee, Y.C., Mims, M.P., Hughes, A., Montgomery, C.D., Roberts, J.D., Parter, T.S., Levine, D.M., and Woo, S.L.C.. In vivo gene therapy forhyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene. J. Clin. Invest., 95:768-773, 1995.
  28. Yuan, L.., Huang, S., Lo, W.H.Y., Fang, B., Wang, M., Wang, T., Sun, G., Zhao, M., Liu, S., and Ye, J. Prenatal gene diagnosis of classical phenylketonuria in 16 pregnancies with high risk. Chinese Journal of Medical Genetics, 12:327-329, 1995.
  29. Le, H., Xie, J.Y., Fang, B., Huang, S., Wang, M., Shi, H.P., Tang, X., Gao, X., and Lo, W.H.Y. Gene diagnosis of Wilson's disease. Chinese Journal of Neurology, 28:195-198, 1995.
  30. Yuan, L., Gao, Y., Lo, S., Fang, B., and Ye, J. Prediction of retinoblastoma: linkage analysis of families with hereditary retinoblastoma by using polymorphic sites within the Rb gene. Acta Academiae Medicinae Sinicae, 17:338-342, 1995.
  31. Huang, S., Fang, B., Chu, H., Yuan, F., Wang, M., Xu, S. and Luo, H.Y. Analysis of short tandem repeats polymorphism in the phenylalanine hydroxylase gene and its application to prenatal gene diagnosis of phenylketonuria. Chin. Med. J., 75:22-24, 1995.
  32. Fang, B., Eisensmith, R.C., Wang, H., Gordon, G., Bellinger, D.A., Read, M.S., Brinkhous, K.M., and Woo, S.L.C. Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and dogs. Gene Ther., 3:217-222, 1996.
  33. Yang, T., Yuan, S.., Huang, S., Fang, B., Wang, M., Gu, G., Min, S., and Lo, W.H.Y. Detection of the mutational gene in phenylketonuria and prenatal diagnosis by usingsingle strand conformation polymorphism methods. Chinese Journal of Obstet. Gynecol., 67:401-403, 1996.
  34. Yan, F., Huang, S., Gao, X., Wang, M., Fang, B., Li, H., and Lo, W.H.Y. Confirming the cause of inherited chronic chorea in Chinese patients. Chinese Medical Journal, 76:197-199, 1996.
  35. Wang, C., Zhang, H., Fang, B. [The relationship between peripheral edema and right heart function in COPD induced cor pulmonale]. Chung Hua I Hsueh Tsa Chih, 76:531-533, 1996.
  36. Huang, S., Li, H., Miao, S., Xu, L., Fang, B., Liu, G., and Luo, H. Analysis of the A/C polymorphic site within the phenylalanine hydroxylase gene. Acta Genetica Sinica, 23:169-73, 1996.
  37. Fang, B., Koch, P., Bouvet, M., Ji, L., and Roth, J.A. A packaging system for SV40 vectors without viral coding sequences. Anal. Biochem, 254:139-143, 1997.
  38. Fang, B., Koch, P., and Roth, J.A. Diminishing adenovirus gene expression and viral replication by promoter replacement. J. Virol., 71:4798-4803, 1997.
  39. Bouvet, M., Ellis, L.M., Liu, W., Fang, B., and Roth, J.A. Adenovirally mediated wild-type p53 gene therapy downregulates vascular endothelial growth factor expression in human colon cancer. Surg. Forum, 48:806-809, 1997.
  40. Bouvet, M., Bold, R.J., Lee, J., Evans, D.B., Abbruzzesse, J.L., Chiao, P.J., McConkey, D.J., Chandra, J., Fang, B., and Roth, J.A. Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer. Ann. Surg. Oncol., 5:681-688, 1998.
  41. Fang, B., Xu, B., Koch, P., and Roth, J.A. Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells. Gene Ther., 5:1420-1424, 1998.
  42. Bouvet, M, Ellis, L.M., Nishizaki, M., Fujiwara, T., Liu, W., Bucana, C.D., Fang, B., Lee, J.J., and Roth, J.A. Adenovirus-mediated wild-type p53 gene transfer downregulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res., 58:2288-2292, 1998.
  43. Fang, B., Ji, L., Bouvet, M., and Roth, J.A. Evaluation of GAL4/TATA in vivo: induction of transgene expression by adenovirally mediated gene codelivery. J. Biol. Chem., 273: 4972-4975, 1998.
  44. Bouvet, M., Fang, B., Ekmekcioglu, S., Ji, L., Bucana, C.D., Hamada, K., Grimm, E.A., and Roth, J.A. Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide. Gene Ther., 5:189-195, 1998.
  45. Ji, L., Bouvet, M., Price, R., Roth, J.A., and Fang, B. Reduced toxicity, attunuated immunogenicity, and efficient mediation of human p53 gene in vivo by an adenovirus vector with deleted E1-E3 and inactivated E4 by GAL4-TATA promoter replacement. Gene Ther., 6:393-402, 1999.
  46. Ji, L., Fang, B., and Roth, J.A. A rapid, sensitive, and nonradioactive method for assay of FHIT Ap3A hydrolase activity by fluorescence TLC image analysis. Anal Biochem., 271:114-116, 1999.
  47. Ji, L., Fang, B., Yen, N., Fong, K., Minna, J.D., and Roth, J.A. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression. Cancer Res., 59:3333-3339, 1999.
  48. Mohan, P.M., Chintala, S.K., Mohanam, S., Gladson, C.L., Kim, E.S., Gokaslan, Z.L., Lakka, S.S., Roth, J.A., Fang, B., Sawaya, R., Kyritsis, A.P., and Rao, J.S. Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth. Cancer Res., 59:3369-3373, 1999.
  49. Pearson, A.S., Koch, P.E., Atkinson, N., Xiong, M., Finberg, R.W., Roth, J.A., and Fang, B. Factors limiting adenovirus mediated gene transfer to human lung and pancreatic cancer lines. Clin. Cancer Res., 5:4208-4213, 1999.
  50. Chen, Y.Q., Hsieh, J.T., Yao, F.Y., Fang, B.L., Pong, R.C., Cipriano, S.C., and Krepulat, F. Induction of apoptosis and G2/M cell cycle arrest by DCC. Oncogene, 18:2747-2754, 1999.
  51. Kagawa, S., Pearson, S.A., Ji, L. Xu, K., McDonnell, T.J., Swisher, S.G., Fang, B., and Roth, J.A. A novel binary vector can mediate expression of the death effector protein bax in human lung cancer cells. Surg. Forum, L:344-346, 1999.
  52. Gu, J., Kagawa, S., Takakura, M., Kyo, S., Inoue, M., Roth, J.A., and Fang, B. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Cancer Res., 60:5359-5364, 2000.
  53. Sueoka, N., Lee, H., Walsh, G., Fang, B., Ji, L., Roth, J.A., LaPushin, R., Hong, W., Cohen, P., and Kurie, J. Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells. Oncogene, 19:4432-4436, 2000.
  54. Sueoka, N., Lee, H-Y., Walsh, G.L., Fang, B., Ji, L., Roth, J.A., LaPushin, R., Hong, W.K., Cohen, P., and Kurie, J.M. Insulin-like growth factor binding protein-6 inhibits the growth of human bronchial epithelial cells and increases in abundance with All-trans-retinoic acid treatment. Am. J. Respir. Cell. Mol. Biol., 23:297-303, 2000.
  55. Yen, N., Ioannides, C.G., Xu, K., Swisher, S. G., Lawrence, D.D., Kemp, B.L., el-Naggar, A.K., Cristiano, R.J., Fang, B., Glisson, B.S., Hong, W.K., Khuri, F.R., Kurie, J.M., Lee, J.J., Lee, J.S., Merritt, J.A., Mukhopadhyay, T., Nesbitt, J.C., Nguyen, D., Perez-Soler, R., Pisters, K.M.W., Putnam, J.B., Jr., Schrump, D.S., Shin, D.M. Walsh, G.L., and Roth, J.A. Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumor injection of an adenovirus vector expressing wild-type p53 (Ad-p53). Cancer Gene Ther., 7:530-536, 2000.
  56. Kagawa, S., Gu, J., Swisher, S.G., Ji, L., Roth, J.A., Lai, D., Stephens, L.C., and Fang, B. Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53-resistant cancer lines. Cancer Res., 60:1157-1161, 2000.
  57. Kagawa, S., Pearson, S.A., Ji, L., Xu, K., McDonnell, T.J., Swisher, S.G., Roth, J.A., and Fang, B. A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax. Gene Ther., 7:75-79, 2000.
  58. Pataer, A., Fang, B., Yu, R., Kagawa, S., Hunt, K.K., McDonnel, T.J., Roth, J.A., and Swisher, SG. Adenoviral bak overexpression mediates caspase-dependent tumor killing. Cancer Res., 60:788-792, 2000.
  59. Pataer, A., Smythe, W.R., Yu, R., Fang, B., McDonnell, T., Roth, J.A., and Swisher, S.G. Adenovirus-mediated bak gene transfer induces apoptosis in mesothelioma cell lines. J. Thorac. Cardiovasc. Surg., 121:61-67, 2001.
  60. Koch, P.E., Guo, Z.S., Kagawa, S., Gu, J., Roth, J.A., and Fang, B. Augmenting transgene expression from carcinoembryonic antigen (CEA) promoter via a GAL4 gene regulatory system. Molec. Ther., 3:278-283, 2001.
  61. Li, X., Marani, M., Yu, J., He, Z., Fang, B., Roth, J.A., Denner, L., and Marcelli, M. Adenoviral-mediated bax overexpression for the induction of therapeutic apoptosis in prostate cancer. Cancer Res., 61:186-191, 2001.
  62. Kagawa, S., He, C., Gu., J., Koch, P., Rha, S.J., Roth, J.A., Curley, S.A., Stephens, L.C., and Fang, B. Antitumor activity and bystander effects of the TNF-related apoptosis-inducing ligand (TRAIL) gene1. Cancer Res., In press, 2001.
  63. Kagawa, S., Gu, J., McDonnell, T.J., Swisher, S.G., Roth, J.A., and Fang, B. Deficiency of caspase-3 in MCF7 cells blocks bax-mediated nuclear fragmentation but not cell death. Clin. Cancer Res., In press, 2001.

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