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  W. Roy Smythe, M.D.
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Bibliography- W. Roy Smythe, M.D.

Published and accepted articles in refereed journals:

  1. Brayman, K.L., Dafoe, D.C., Smythe, W.R., Barker, C.F., Perloff, L.J., Naji, A., Fox, I.J., Grossman , R.A., Jorkasky, P.K., and Starr, E. Prophylaxis of serious cytomegalovirus infection in renal transplant patients using live human cytomegalovirus vaccine. Arch. Surg., 123:1502-1508, 1988.
  2. Dafoe, D.C., Smythe, W.R., Berezniak, R., Tafra, L., Shaw, L.M., Tomaszewski, J.E. and Barker, C.F An innovative site for pancreas transplantation in rats - the subserosa of a U-loop of small intestine. Transplantation, 48:863-865,1989.
  3. Mandelbrot, D.A., Smythe, W.R., Norman, S.A., Martin, S.C., Arnold, R.M., Talbot, G.H., and Stolley, P.D. A survey of exposures, practices and recommendations of surgeons in the case of patients with the human immunodeficiency virus. Surg. Gynecol. Obstet. 171:99-106, 1990.
  4. Alfrey, E.J., Smythe, R., Freidman, A., Meranze, S., Grossman, R.A., Perloff, L.J., Naji, A., Barker, C.F., and Dafoe, D.C. Two masqueraders of transplant renal artery stenosis (TRAS). Clin. Transplant., 7:183, 1993.
  5. Smythe, W.R., LeBel, E., Litzky, L.A., Kaiser, L.R., Bavaria, J.E., and Albelda, S.M. Non-small cell lung carcinoma angiogenesis and nodal metastasis. Am. Rev. Respir. Dis., 147S(4):A328, 1993.
  6. Smythe, W.R., and Bavaria, J.E. Tetracycline pleurodesis--associated acute renal failure. Chest, 104:1274-1276, 1993.
  7. Smythe, W.R., Hwang, H.C., Amin, K.M., Eck, S.L., Davison, B.L., Wilson, J.M., Kaiser, L.R., and Albelda, S.M. Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system. Cancer Res., 54:2055-2059, 1994.
  8. Smythe, W.R., Kaiser, L.R., Hwang, H.C., Amin, K.M., Pilewski, J.M., Eck, S.L., Wilson, J.M, and Albelda, S.M. Successful adenovirus-mediated gene transfer in an in vivo model of human malignant mesothelioma. Ann. Thorac. Surg., 57:1395-1401, 1994.
  9. Smythe, W.R., Hwang, H.C., Amin, K.M., Wilson, J.M., Albelda, S.M., and Kaiser, L.R. Significant survival benefit following adenovirus-mediated gene therapy for experimental malignant mesothelioma. Surgical Forum,80:499-500, 1994.
  10. Smythe, W.R., Bavaria, J.E., Hall, R.A., Kline, G.M., and Kaiser, L.R. Thoracoscopic removal of mediastinal parathyroid adenoma. Ann. Thorac. Surg., 59:236-238, 1995.
  11. Smythe, W.R., Hwang, H.C., Elshami, A.A., Amin, K.M., Albelda, S.M, and Kaiser, L.R.. Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy. J. Thorac. Cardiovasc. Surg., 109:626-631, 1995.
  12. Amin, K.M., Litzky, L.A., Smythe, W.R., Mooney, A.M., Morris, J.M., Mews, D.J., Pass, H.I., Kair, C., Rodeck, U., and Rauscher, 3rd, F.J. Wilms' tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma. Am. J. Pathol., 146:344-356, 1995.
  13. Smythe, W.R., Hwang, H.C., Elshami, A.A., Amin, K.M., Eck, S.L., Davidson, B.L., Wilson, J.M., Kaiser, L.R., and Albelda, S.M. Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann. Surg., 222:78-86, 1995.
  14. Hwang, H.C., Smythe, W.R., Elshami, A.A., Kucharczuk, J.C., Amin, K.M., Williams, J.P., Litzky, L.A., Kaiser, L.R., and Albelda, S.M. Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer. Am. J. Respir. Cell Mol. Biol., 13:7-16, 1995.
  15. Smythe, W.R., LeBel, E., Bavaria, J.E., Kaiser, L.R., and Albelda, S.M. Integrin expression in non-small cell carcinoma of the lung. Cancer Metastasis Rev., 14:229-239, 1995.
  16. Kucharczuk, J.C., Elshami, A.A., Hong, B.Z., Smythe, W.R., Hwang, H.C., Tomlinson, J.S., Amin, K.M., Litzky, L.A., Albelda, S.M., and Kaiser, L.R. Pleural-based mesothelioma in immune competent rats: a model to study adenoviral gene transfer. Ann. Thorac. Surg., 60:593-598, 1995.
  17. Elshami, A.A., Kucharczuk, J.C., Sterman, D.H., Smythe, W.R., Hwang, H.C., Amin, K.M., Litzky, L.A., Albelda, S.M., and Kaiser, L.R. The role of immunouppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann. Surg., 222:298-310, 1995.
  18. Elshami, A.A., Kucharczuk, J.C., Zhang, H.B., Smythe, W.R., Hwang, H.C., Litzky, L.A., Kaiser, L.R., and Albelda, S.M. Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene. Hum. Gene Ther., 7:141-148, 1996.
  19. Smythe, W.R., and Carpenter, J.P. Upper abdominal aortic injury during spinal surgery. J. Vasc. Surg., 25:774-777, 1997.
  20. Smythe, W.R., Wasfi, D., Bavaria, J.E., Albelda, S.M., and Kaiser, L.R. Loss of alpha-v integrin expression and recurrence in node-negative lung carcinoma. Ann. Thorac. Surg., 64:949-953, 1997.
  21. Roberts, J.R., Smythe, W.R., Weber, R.W., Lanutti, M., Rosengard, B.R., and Kaiser, L.R. Thoracoscopic management of descending necrotizing mediastinitis. Chest, 112:850-854, 1997.
  22. Liu, M., Kim, P.S., Chen, C.K., and Smythe, W.R. Delayed Horner's syndrome as a complication of continuous thoracic epidural analgesia. J. Cardiothorac. Vasc. Anesth., 12:195-196, 1998.
  23. Roberts, J.R., Abbott, P.S., Smythe, W.R., and Bavaria, J.E. Resection of a pulmonary malignancy invading the intrapericardial inferior vena cava. Ann. Thorac. Surg., 65:263-265, 1998.
  24. Smythe, W.R., Bavaria, J.E., and Kaiser, L.R. Mediastinoscopic subtotal removal of mediastinal cysts. Chest, 114:614-617, 1998.
  25. Taichman, D.B., Tino, G., Aronchick, J., Reynolds, C., Smythe, W.R., Roberts, J.R., and Haller, D. Diffuse airway narrowing from carcinoma metastatic to the bronchial submucosa: identification by chest CT. Chest, 114:1217-1220, 1998.
  26. Stewart, A.S. Smythe, W.R., Aukburg, S., Kaiser, L.R. Fox, K.R., and Bavaria, J.E. Severe acute extrinsic airway compression by mediastinal tumor successfully managed with extracorporeal membrane oxygenation. ASAIO J. 44:219-221, 1998.
  27. Smythe, W.R., Gorman, R.C., DeCampli, W.M., Spray, T.L., Kaiser, L.R., and Acker, M.A. Management of exsanguinating hemoptysis during cardiopulmonary bypass. Ann. Thorac. Surg., 67:1288-1291, 1999.
  28. Smythe, W.R., Williams, J.P., Wheelock, M.J., Johnson, K.R., Kaiser, L.R., and Albelda, S.M. Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer. Lung Cancer, 24:157-168, 1999.
  29. Smythe, W.R., Benjamin Rush's death. J. Am. Coll. Surg., 190:471-482, 2000.
  30. Swisher, S.G., DeFord, L., Merriman, K.W., Walsh, G.L., Smythe, R., Vaporciyan, A., Ajani, J.A., Brown, T., Komaki, R., Roth, J.A., and Putnam, J.B. Effect of operative volume on morbidity, mortality and hospital use after esophagectomy for cancer. J. Thorac. Cardiovasc. Surg., 119:1126-1134, 2000.
  31. Putnam, J.B., Jr., Walsh, G.L., Swisher, S.G., Roth, J.A., Suell, D.M., Vaporciyan, A.A., Smythe, W.R., Merriman, K.W., and DeFord, L.L. Outpatient management of malignant pleural effusion by a chronic indwelling pleural catheter. Ann. Thorac. Surg., 69:369-75, 2000.
  32. Smythe, W.R., Bridges, N.D., Gaynor, J.W., Nicolson, S., Clark, B.J., and Spray, T.L. Bilateral sequential lung transplant for ectodermal dysplasia. Ann. Thorac. Surg., 70:654-656, 2000.
  33. Mohiuddin, I., Cao, X., and Smythe, W.R. Sodium butyrate markedly augments proapoptotic gene therapy via alterations in bcl-3 family protein expression. Surgical Forum, 51:118-120, 2000.
  34. Walsh, G.L., Davis, B.M., Swisher, S.G., Vaporciyan, A.A., Smythe, W.R., Merriman, K.W., Roth J.A., and Putnam, J.B., Jr. A single-institutional multidisciplinary approach to primary sarcomas involving the chest wall requiring full- thickness resections. J. Thorac. Cardiovasc. Surg., 121:48-60, 2001.
  35. Pataer, A., Smythe, W.R., Yu, R., Fang, B., McDonnell, T., Roth, J.A., and Swisher, S.G. Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J. Thorac. Cardiovasc. Surg., 121:61-67, 2001.
  36. Smythe, W.R., Estrera, A.L., Swisher, S.G., Merriman, K.W., Walsh, G.L., Putnam, J.B., Jr., Vaporciyan, A.A., and Roth J.A. Surgical resection of non-small cell carcinoma after treatment for small cell carcinoma. Ann. Thorac. Surg., 71:962-966, 2001.
  37. Siegenthaler, M.P., Pisters, K.M., Merriman, K.W., Roth, J.A., Swisher, S.G., Walsh, G.L., Vaporciyan, A.A., Smythe, W.R., and Putnam J.B., Jr. Preoperative chemotherapy for lung cancer does not increase surgical morbidity. Ann Thorac. Surg., 71:1105-1112, 2001.
  38. Mohiuddin, I., Cao, X., Fangm B., Nishizaki, M., and Smythe, W.R. Significant augmentation of pro- apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma. Cancer Gene Ther., 8:547-554, 2001.
  39. Cao, X.X/, Mohuiddin, I., Ece, F., McConkey, D.J., and Smythe, W.R. Histone ceacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma. Am. J. Respir. Cell Mol. Biol., 25:562-568, 2001.
  40. Ajani, J., Koamki, R., Putnam, J.B., Walsh, G., Nesbitt, J., Pisters, P.W., Lynch, P.M., Vaporciyan, A., Smythe, W.R., Lahoti, S., Raijman, I., Swisher, S., Martin, F.D., and Roth, J.A. A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junction. Cancer, 92:279-286, 2001.
  41. Han, X.Y., Pham. A.S., Nguyen, K.U., Smythe, W.R., Ordonez, N.G., Jacobson, K.L., and Tarrand, J.J. Pulmonary granuloma caused by Pseudomonas andersonii sp nov. Am. J. Clin. Path., 116:347-353, 2001.
  42. Swisher, S.G., Wynn, P., Putnam, J.B., Mosheim, M.B., Correa, A.M., Komaki, R.R., Ajani, J.A., Smythe, W.R., Vaporciyan, A.A., Roth, J.A., and Walsh, G.L. Salvage esophagectomy for recurrent tumors after definitive chemotherapy and radiotherapy. J. Thorac. Cardiovasc. Surg., 123:175-183, 2002.
  43. Vaporciyan, A.A., Merriman, K.W., Ece, F., Roth, J.A., Smythe, W.R., Swisher, S.G., Walsh, G.L., Nesbitt, J.C., and Putnam, J.B., Jr. Impact of timing of smoking cessation on pulmonary morbidity after pneumonectomy. Ann. Thorac. Surg., 73:420-425, 2002.
  44. Smythe, W.R., Mohuiddin, I., Ozveran, M., and Cao, X. Antisense therapy for malignant mesothelioma utilizing oligonucleotides targeting the bcl-xl gene product. J. Thorac. Cardiovasc. Surg., 123:1191-1198, 2002.
  45. Mohiuddin, I., Cao, X., Ozveran, M., Zumstein, L., Chada, S., Smythe, W.R. Phosphatase and tensin analog gene overexpression engenders cellular death in human malignant mesothelioma cells via inhibition of AKT phosphorylation. Ann. Surg. Oncol., 9:310-316, 2002.
  46. Smythe, W.R. The first American textbook of surgery. Annals of Surgery, in press, 2002.
  47. Forster, K.M., Smythe, W.R., Starkschall, G., Liao, Z., Takanaka, T., Kelly, J.F., Vaporciyan, A., Ahamad, A., Dong, L., Salehpour, M., Komak,i R., and Stevens, G.W. Intensity modulated radiation therapy following extrapleural pneumonectomy for the treatment of malignant mesothelioma: clinical implementation. Intl. J. Radiat. Oncol. Biol. Physics, in press, 2002.

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