Introduction Section 1 Section 2 Section 3 Conclusion and References


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Section 2 - Other CNS disease related to underlying and secondary effects of malignancy

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Infection: Sinusitis

Sinusitis is common in leukemics. Typical organisms affecting the above regions as well as the paranasal sinuses are the gram negative bacilli such as E. coli, P. aeruginosa, and K. pneumonia. While many of these organisms are readily treated or prophylaxed against with antibiotics, the end result may be suppression of the normal nasal flora leading to implantation and proliferation of Aspergillus fungal species in the sinonasal cavity. Aspergillus sinusitis can present with variable symptoms and may include a foul smelling discharge. In leukemics, this infection may be very aggressive, resulting in bone destruction and extension into adjacent spaces ( case 17), or intracranially.


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