 2000
Publications
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Liposomal
Bcl-2 antisense oligonucleotides enhance proliferation,
sensitize acute myleoid leukemia to cytosine-arabinoside,
and induce apoptosis independent of other antiapoptotic
proteins
Konopleva, M., Tari, A.M., Estrov, Z., Harris, D., Xie,
Z., Zhao, S., Lopez-Berestein, G., and Andreeff, M.
Blood, 95:3929-3938, 2000.
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Cell-penetrating
Crkl SH3 domain blocker peptides inhibit proliferation of
primary blast cells from CML patients
Kardinal, C., Konkol., B., Schulz, A., Posern, G., Lin,
H., Adermann, K., Eulitz, M., Estrov, Z., Talpaz, M., Arlinghaus,
R.B., and Feller S.M.
FASEB J., 14:1529-1538, 2000.
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Expression
of retinoid-inducible tumor suppressor, tazarotene-inducible
gene-3, is decreased in psoriasis and skin cancer
Duvic, M., Helekar, B., Schulz, C., Cho, M., DiSepio, D.,
Hager, C., DiMao, D., Hazarika, P., Jackson, B., Breuer-McHam,
J., Yound, J., Clayman, G., Lippman, S.M., Chandraratna,
R.A.S., Robinson, N.A., Deucher, A., Eckert, R.L., and Nagpal,
S.
Clin. Cancer Res., 6:3249-3259, 2000.
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Telomerase
activity in head and neck tumors following introduction of
wild-type p53, p21, p16 and EsF-1 genes via recombinant adenovirus
Henderson, Y.C., Breau, R.L., Liu, T.-J., and Clayman, G.L.
Head and Neck, 22:347-354, 2000. |
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Insulin-like
growth factor binding protein-6 activates programmed cell
death in non-small cell lung cancer cells
Sueoka, N., Lee, H.., Walsh, G., Fang, B., Ji, L., Roth, J.A.,
LaPushin, R., Hong, W., Cohen, P., and Kurie, J.
Oncogene 19:4432-4436, 2000. |
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Insulin-like
growth factor binding protein-6 inhibits the growth of human
bronchial epithelial cells and increases in abundance with
All-trans-retinoic acid treatment
Sueoka, N., Lee, H.-Y., Walsh, G.L., Fang, B., Ji, L., Roth,
J.A., LaPushin, R., Hong, W.K., Cohen, P., and Kurie, J.M.
Am. J. Respir. Cell. Mol. Biol., 23:297-303, 2000. |
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Adenoviral
bak overexpression mediates caspase dependent tumor killing
Pataer, A., Fang, B., Yu, R., Kagawa, S., Hunt, K.K., McDonnell,
T.J., Roth, J.A., and Swisher, S.G.
Cancer Res., 60:788-792, 2000. |
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Gene therapy using direct in vivo gene injection
Fang, B. and Roth, J.A.
In: S.A. Rosenberg (ed), Principles
and Practice of the Biologic Therapy of Cancer, 3rd edition,
796-810, Philadelphia, Lippincott Williams & Wilkins, 2000. |
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Expression
of costimulatory molecules CD80 and CD86 and their receptors
CD28, CTLA-4 on tumor infiltrating lymphocytes from patients
with ovarian and other types of peritoneal carcinomatosis
Melichar, B., Nash, M.A., Lenzi, R., Platsoucas, C.D., and
Freedman, R.S.
Clin. Exp. Immunol., 119:19-27, 2000. |
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Intraperitoneal
radioimmunotherapy with human monoclonal IGM in nude mice
with peritoneal carcinomatosis
Borchardt, P.E., Quadri, S.M., Freedman, R.S., and Vriesendorp,
H.M.
Cancer Biother. Radiopharmaceuticals, 15:53-64, 2000. |
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Clinical
and biological effects of intraperitoneal injections of recombinant
interferon-gamma and recombinant interleukin-2 with or without
tumor-infiltrating lymphocytes in patients with ovarian or
peritoneal carcinoma
Freedman, R.S., Kudelka, A. P., Kavanagh, J.J., Verschraegen,
C., Edwards, C.L., Nash, M., Levy, L., Atkinson, E.N., Zhang,
H.-Z., Melichar, B., Patenia, R., Templin, S., Scott, W.,
and Platsoucas, C.D.
Clin. Cancer Res., 6:2268-2278, 2000. |
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High-dose
ifosfamide and etoposide with filgrastim for stem cell mobilization
in patients with advanced ovarian cancer
Donata, M.L., Gershenson, D., Ippoliti, C., Wharton, J.T.,
Bast, R.C., Jr., Aleman, A., Anderlini, P., Gajewski, J.G.,
Giralt, S., Molldrem, J., Uteno, N., Lauppe, J., Korbling,
M., Boyer, J., Bodurka-Bevers, D., Bevers, M., Burke, T.,
Freedman, R., Wolf, J., and Champlin, R.E.
Bone Marrow Transplant, 25:1137-1140, 2000. |
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IL-12
activation of NK cells: Involvement of MKK1/2/ERK but not
p38 kinase pathway
Yu, T-K, Caudell, E.G., Smid, C., and Grimm, E.A.
J. Immunol. 164:6244-6251, 2000. |
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Characterization
of human copine III as a phosphoprotein with associated kinase
activity
Caudill, E.G., Caudill, J.J., Tang, C.-H., Yu, T.-K., Frederick,
M., and Grimm, E.A.
Biochemistry, 39:13034-13043, 2000. |
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Unexpected
cytokines in serum of malignant melanoma patients during sequential
biochemothrapy
Grimm, E.A., Smid, C.M., Lee, J.J., Tseng, C.-H., Eton, O.,
and Buzaid, A.C.
Clin. Cancer Res., 6:3895-3903 2000. |
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A
binary adenoviral vector system for expressing high levels
of the proapoptotic gene bax
Kagawa, S., Pearson, S.A., Ji, L., Xu, K., McDonnell, T.J.,
Swisher, S.G., Roth, J.A., and Fang, B.
Gene Ther., 7:75-79, 2000. |
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Overexpression
of the wild-type p-53 gene inhibits NF-kappaB activity and
synergizes with aspirin to induce apoptosis in human colon
cancer cells
Shao, J., Fujiwara, T., Kadowaki, Y., Fukazawa, T., Waku,
T., Itoshima, T., Yamatsuji, T., Nishizaki, M., Roth, J.A.,
and Tanka, N.
Oncogene, 19:726-736, 2000. |
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Down-regulation
of bel-2 is associated with p16INK4-mediated apoptosis in
non-small cell lung cancer cells
Kataoka, M., Wiehle, S., Spitz, F., Schumacher, G., Roth,
J.A., and Cristiano, R.J.
Oncogene 19:1589-1595, 2000. |
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Synergistic
effects of adenovirus expressing wild-type p53 on chemosensitivity
of non-small cell lung cancer cells
Horio, Y., Hasegawa, Y., Sekido, Y., Takahashi, M., Roth,
J.A., and Shimokata, K.
Cancer Gene Ther. 7:4:537-544, 2000. |
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Fas
and Fas ligand interactions in malignant disease (review)
Owen-Schaub, L., Chan, H., Cusack, J.C., Roth, J.A., and Hill,
L.L.
Int. J. Oncol., 17:5-12, 2000. |
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Multiple
molecular marker testing (p53, C-KI-RAS, C-ERBB-2) improves
estimation of prognosis in potentially curative resected
non-small cell lung cancer
Schneider, P.M., Praeuer, H.W., Boehm, J., Manning, J.,
Metzger, R., Fink, U., Wegerer, S., Hoelscher, A.H. and
Roth,
J.A.
Br. J. Cancer, 83:473-479, 2000.
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Induction
of apoptosis in human esophageal cancer cells by sequential
transfer of the wild-type p53 and E2F-1 genes: involvement
of p53 accumulation via ARF-mediated MDM2 downregulation.
Itoshima, T., Fujiwara, T., Waku, T., Shao, J., Kataoka, M.,
Yarbrough, W.G., Liu, T.-J., Roth, J.A., Tanaka, N., and Kodama,
M.
Clin. Cancer Res., 6:2851-2859, 2000. |
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p53
mutational status improves estimation of prognosis in patients
with curatively resected adenocarcinoma in Barrett's esophagus.
Schneider, P.M., Stoeltzing, O., Roth, J.A., Hoelscher, A.H.,
Wegerer, S., Mizuomoto, S., Becker, K., Dittler, H.J., Fink,
U., and Siewert, J.R.
Clin. Cancer Res., 6:3153-3158, 2000. |
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Oral
administration of an estrogen metabolite induced potentiation
of radiation antitumor effects in presence of wild-type p53
in non-small cell lung cancer.
Huober, J.B., Nakamura, S., Meyn, R., Roth, J.A., and Mukhopadhyay,
T.
Int. J. Rad. Oncol. Biol. Phys., 48:1127-1137, 2000. |
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Contribution
of CD95 ligand-induced neutrophil infiltration to the bystander
effect in p53 gene therapy for human cancer.
Waku, T., Fujiwara, T. Shao, J., Itoshima, T., Murakami, T.,
Kataoka, M., Gomi, S., Roth, J.A., and Tanaka, N.
J. Imunol., 165:5884-5890, 2000. |
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Adenoviral-mediated
p16INK4a gene expression radiosensitizes non-small cell lung
cancer cells in a p53-dependent manner.
Kawabe, S., Roth, J.A., Meyn, R.
Oncogene, 19:5359-5364, 2000. |
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Tumor-suppressive
effects by adenovirus-mediated mda-7 gene transfer in non-small
cell lung cancer in vitro.
Saeki, T., Mhashilkar, A., Chada, S., Branch, C., Roth, J.A.,
and Ramesh, R.
Gene Ther., 7:2051-2057, 2000. |
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Prostate
cancer radiosensitization in vivo with adenovirus-mediated
p53 gene therapy.
Cowen, D., Salem, N. Ashoori, F., Meyn, R., Meistrich, M.L.,
Roth, J.A., and Pollack, A.
Clin. Cancer Res., 6:4402-4408, 2000. |
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Molecular
events in bronchogenic carcinoma and their implications for
therapy.
Toloza, E.M., Roth, J.A., and Swisher, S.G.
Semin. Surg. Oncol., 18:91-99, 2000. |
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Gene
replacement strategies for treating non-small cell lung cancer.
Roth, J.A., Grammer, S.F., Swisher, S.G., Nemunaitis, J.,
Merritt, J., and Meyn, R.E.,Jr.
Sem. Radiat., Oncol., 4:333-342, 2000. |
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Prodrug/Drug
sensitivity gene therapy: current status.
Smythe, W.R.
Curr. Oncol. Rep., 2:17-22, 2000. |
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Gene
therapy in lung cancer.
Swisher, S.G., and Roth, J.A.
Curr. Oncol. Rep., 2:64-70, 2000. |
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Adenovirus-mediated
p53 gene transfer in sequence with cisplatin to tumors of
patients with non-small cell lung cancer.
Nemunaitis, J., Swisher, S.G., Timmons, T., Connors, D., Mack,
M., Doerksen, L., Weill, D., Wait, J., Lawrence, D.D., Kemp,
B.L., Fossella, F., Glisson, B.S., Hong, W.K., Khuri, F.R.,
Kurie, J.M., Lee, J.J., Lee, J.S., Nguyen, D.M., Nesbitt,
J.C., Perez-Soler, R., Pisters, K.M.W., Putnam, J.B., Jr.,
Richli, W.R., Shin, D.M., Walsh, G.L., Merritt, J., and Roth,
J.A.
J. Clin. Oncol., 18:609-622, 2000. |
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Up-regulation
of the proapoptotic mediators bax and bak after adenovirus-mediated
p53 gene transfer in lung cancer cells.
Pearson, A.S., Spitz, F.R., Swisher, S.G., Kataoka, M., Sarkiss,
M.G., Meyn, R.E., McDonnell, T.J., Cristiano, R.J., and Roth,
J.A.
Clin Cancer Res., 6:887-890, 2000. |
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Cellular
and humoral immune responses to adenovirus and p53 protein
antigens in patients following intratumoral injection of an
adenovirus vector expressing wildtype p53 (Ad-p53).
Yen, N., Ioannides, C.G., Xu, K., Swisher, S.G., Lawrence,
D.D., Kemp, B.L., El-Nagger, A.K., Cristiano, R.J., Fang,
B., Glisson, B.S., Hong, W.K., Khuri, F.R., Kurie, J.M., Lee,
J.J., Lee, J.S., Merritt, J.A., Mukhopadhyay, T., Nesbitt,
J.C., Nguyen, D., Perez-Soler, R., Pisters, K.M.W., Putnam,
J.B., Jr., Schrump, D.S., Shin, D.M., Walsh, G.L., and Roth,
J.A.
Cancer Gene Ther., 7:530-536, 2000. |
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Apoptosis
in lung pathophysiology.
Fine, A., Janssen-Heinninger,Y., Soultanakis, R.P., Swisher,
S.G., and Uhal, B.D.
Am. J. Physiol. Lung Cell Mol. Physiol., 279:L423-L427, 2000. |
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Hammerhead
ribozyme as a therapeutic agent for hyperlipidemia: production
of trunated apolipoprotein B and hypolipidemic effects in
a dyslipidemia murine model.
Enjoji, M., Wang, F., Nakamuta, M., Chan, L., and Teng, B-B.
Hum. Gene Ther., 11:2415-2430, 2000. |
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Intranasal
therapy with an adenovirus vector continuing the murine IL-12
gene eradicates osteosarcoma lung metastases
Worth, L.L., Jia,-F., Zhou, Z., Chen, L., and Kleinerman,
E.S.
Clin. Cancer Res., 6:3713-3718, 2000. |
Archived
1999 Publications
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