| HISTOGRAM
CLASSIFICATION
The classification of cells by 6 types of histograms is
the simplest and most generally accepted method in current use at M. D.
Anderson Cancer Center.
Histogram Patterns by Lymphoma Subtypes
| Lymphoma Subtype* |
L-I
|
L-IA
|
L-II
|
L-IIA
|
L-III
|
L-IIIA
|
| Reactive |
6
|
|
4
|
|
5
|
|
| Small cleaved |
33
|
1
|
1
|
|
|
1
|
| Small lymphocytic |
14
|
|
3
|
|
|
|
| Mixed cell |
5
|
|
5
|
5
|
|
|
| Mantle cell |
1
|
|
3
|
|
|
|
| Large cell |
1
|
1
|
8
|
13
|
11
|
10
|
| Ki-1 |
|
|
|
|
|
4
|
| Immunoblastic |
|
|
|
1
|
1
|
1
|
| Lymphoblastic |
|
|
|
|
|
1
|
| Peripheral T-cell |
|
|
|
1
|
|
|
| Hodgkin's Disease |
1
|
|
1
|
2
|
|
1
|
* According to the working formulation for non-Hodgkin's
Lymphoma.
Note: L-I, L-II, L-III subdivided by proliferation
index: I < 1.2; II < 4.0; III > 4.0. L-IA, L-IIA, L-IIIA are as above
but with hyperdiploid cells (DNA content > 5c).
Relationship between Histogram
Patterns and Grade of Non-Hodgkin's Lymphoma and Reactive Lymph Nodes
| Lymphoma Grade |
L-I, L-IA
|
L-II, L-IIA
|
L-III, L-IIIA
|
Total
|
| Low |
54
|
14
|
3
|
71
|
| Intermediate |
2
|
19
|
18
|
39
|
| High |
0
|
0
|
8
|
8
|
| Reactive |
6
|
4
|
5
|
15
|
| TOTAL |
|
|
|
133
|
Note: According to the Working Formulation for non-Hodgkin's
lymphoma.
Reference: Katz RL, Wojcik EM, Johnston DA:
Image analysis in non-Hodgkin's lymphomas emphasizing applications in tissue
procured by fine needle aspiration. In: GL Wied. ed. Compendium on the
Computerized Cytology and Histology Laboratory, Science Printers and Publishers,
Inc., St. Louis, MO, 1993.
|