| HISTOGRAM
CLASSIFICATION The classification of cells by 6 types of histograms is
the simplest and most generally accepted method in current use at M. D.
Anderson Cancer Center.
Histogram Patterns by Lymphoma Subtypes
 
 
* According to the working formulation for non-Hodgkin's
Lymphoma.
| Lymphoma Subtype* | L-I | L-IA | L-II | L-IIA | L-III | L-IIIA |  
| Reactive | 6 |  | 4 |  | 5 |  |  
| Small cleaved | 33 | 1 | 1 |  |  | 1 |  
| Small lymphocytic | 14 |  | 3 |  |  |  |  
| Mixed cell | 5 |  | 5 | 5 |  |  |  
| Mantle cell | 1 |  | 3 |  |  |  |  
| Large cell | 1 | 1 | 8 | 13 | 11 | 10 |  
| Ki-1 |  |  |  |  |  | 4 |  
| Immunoblastic |  |  |  | 1 | 1 | 1 |  
| Lymphoblastic |  |  |  |  |  | 1 |  
| Peripheral T-cell |  |  |  | 1 |  |  |  
| Hodgkin's Disease | 1 |  | 1 | 2 |  | 1 |  Note: L-I, L-II, L-III subdivided by proliferation
index: I < 1.2; II < 4.0; III > 4.0. L-IA, L-IIA, L-IIIA are as above
but with hyperdiploid cells (DNA content > 5c).
 Relationship between Histogram
Patterns and Grade of Non-Hodgkin's Lymphoma and Reactive Lymph Nodes
 
Note: According to the Working Formulation for non-Hodgkin's
lymphoma.
| Lymphoma Grade | L-I, L-IA | L-II, L-IIA | L-III, L-IIIA | Total |  
| Low | 54 | 14 | 3 | 71 |  
| Intermediate | 2 | 19 | 18 | 39 |  
| High | 0 | 0 | 8 | 8 |  
| Reactive | 6 | 4 | 5 | 15 |  
| TOTAL |  |  |  | 133 |  Reference: Katz RL, Wojcik EM, Johnston DA:
Image analysis in non-Hodgkin's lymphomas emphasizing applications in tissue
procured by fine needle aspiration. In: GL Wied. ed. Compendium on the
Computerized Cytology and Histology Laboratory, Science Printers and Publishers,
Inc., St. Louis, MO, 1993.
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