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Hematologic/ Cerebrovascular: Sinovenous
thrombosis
Sinovenous occlusive disease:
Patients with leukemia are prone to develop sinovenous occlusions (case
16). Prior to the advent of noninvasive imaging, this
complication of leukemia was thought to be rare. However, it is now
being reported with greater frequency and is probably more common than
previously thought. Imaging of this lesion is well-described and not
unique to leukemia. However, the signs and symptoms of dural sinus
thrombosis (headache, papilledema, lethargy) can mimic CNS leukemic
infiltration, and imaging may be required to differentiate. In fact,
both may coexist, with infiltration of the dural sinus wall being
responsible for the thrombosis. As mentioned previously, some
chemotherapeutic agents such as L-asparaginase are known to be
thrombogenic and patients on these drugs are at particular risk for
sinovenous occlusion. Venous infarcts may complicate sinus occlusion.
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©2002
The Levit Radiologic - Pathologic Institute
1100 Holcombe Blvd, Houston, TX 77030
(USA) / 713-792-2728
Last updated; February 2002 - contact
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