Introduction Section 1 Section 2 Section 3 Conclusion and References


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Section 2 - Other CNS disease related to underlying and secondary effects of malignancy

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Hematologic/ Cerebrovascular: Sinovenous thrombosis

Sinovenous occlusive disease: Patients with leukemia are prone to develop sinovenous occlusions (case 16). Prior to the advent of noninvasive imaging, this complication of leukemia was thought to be rare. However, it is now being reported with greater frequency and is probably more common than previously thought. Imaging of this lesion is well-described and not unique to leukemia. However, the signs and symptoms of dural sinus thrombosis (headache, papilledema, lethargy) can mimic CNS leukemic infiltration, and imaging may be required to differentiate. In fact, both may coexist, with infiltration of the dural sinus wall being responsible for the thrombosis. As mentioned previously, some chemotherapeutic agents such as L-asparaginase are known to be thrombogenic and patients on these drugs are at particular risk for sinovenous occlusion. Venous infarcts may complicate sinus occlusion.


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