Introduction Section 1 Section 2 Section 3 Conclusion and References


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Section 3 - Disease related to treatment

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Diffuse necrotizing leukoencephalopathy

    Imaging features of leukoencephalopathy: Imaging features of necrotizing leukoencephalopathy include periventricular white matter hypodensity on CT, and hypo/ hyperintensity on T1/T2-weighted MRI (case 23). With MRI, enhancement may occasionally be seen. MRI has been shown to be more sensitive in the detection of these changes, however imaging findings do not always correlate with clinical status. It has been suggested that monitoring with MRI may detect the earliest phases of therapeutic toxicity so that treatment can be changed. There may be imaging evidence of mineralizing microangiopathy, with calcification in the basal ganglia or subcortical white matter (case 24). Rarely, necrosis may appear mass-like, and mimic neoplasm (case 25). In some cases, the imaging findings are reversible. Enhancement may be seen at the entrance site of the catheter in patients given intraventricular chemotherapy (case 26)

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